Results 111 to 120 of about 4,350,912 (327)

Handling of the generation of primary events in Gauss, the LHCb simulation framework

open access: yesIEEE Nuclear Science Symposuim & Medical Imaging Conference, 2010
The LHCb simulation application, Gauss, consists of two independent phases, the generation of the primary event and the tracking of particles produced in the experimental setup.
I. Beiyaev   +16 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Optimising reliability of mouse performance in behavioural testing: the major role of non-aversive handling

open access: yesScientific Reports, 2017
Handling laboratory animals during test procedures is an important source of stress that may impair reliability of test responses. Picking up mice by the tail is aversive, stimulating stress and anxiety.
Kelly Gouveia, J. Hurst
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Ideal cycle of combustion engine with natural gas as a fuel

open access: yesResearch in Agricultural Engineering, 2016
The aim of the paper is to present a detailed methodology of calculations of parameters of an ideal working cycle of spark-ignition combustion engine. Natural gas in the form of compressed natural gas (CNG) was used as a fuel.
I. Vitázek   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Exploratory piloted simulator study of the effects of winglets on handling qualities of a representative agricultural airplane [PDF]

open access: yes
The effects on handling qualities of adding winglets to a representative agricultural aircraft configuration during swath-run maneuvering were evaluated.
Brown, P. W., Ogburn, M. E.
core   +1 more source

Handling Missing Data in Clinical Research.

open access: yesJournal of Clinical Epidemiology, 2022
M. Heymans, J. Twisk
semanticscholar   +1 more source

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