Results 121 to 130 of about 4,350,912 (327)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
MATEC Web of Conferences, 2018 In urban railway environments, in many respects, the problem of tramcars passing small radius arches appears to be topical. In this regard, the authors proposed that the wheelsets should be complemented on the outer side of the wheels with a second tread
Hauser Vladimír +3 more
doaj +1 more source
Elimination of ecological fluids contamination in agricultural tractors
Research in Agricultural Engineering, 2014 This contribution presents the elimination of pollution for ecological fluids of UTTO (universal tractor transmission oils) type in agricultural tractors.
R. Majdan +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Hoisting frame facilitates handling of large objects [PDF]
, 1968 Hoisting frame can be used with a standard 5-ton forklift to handle the large spreader bars, or other bulky pieces of equipment, much faster and more efficiently than with a boom or gantry crane.
Colpean, K. V., Holcomb, D. F.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Device for handling printed circuit cards Patent [PDF]
, 1971 Handling tool for printed circuit ...
West, R. L.
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Research of the possibility of using beams with corrugated walls in a passenger rail car frame
Scientific ReportsThe material of the article provides a scientific evaluation of the feasibility of using beams with corrugated walls in the passenger rail car frame structure. Such a decision will allow to reduce the material amount of the passenger rail car sprung mass
Alyona Lovska, Juraj Gerlici, Ján Dižo
doaj +1 more source