Results 41 to 50 of about 1,382,820 (296)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Efficient Messaging through Cluster Coordinators in Decentralized Controlled Material Flow Systems

MATEC Web of Conferences, 2016
The modularization of the hard- and software is one approach handling the demand for increasing flexibility and changeability of automated material flow systems. A control that is distributed across several different hardware controllers leads to a great
Lieberoth-Leden Christian, Regulin Daniel, Günthner W.A.   +2 more
doaj   +1 more source

Quality assurance in moving and handling education: myth or legend

Pielęgniarstwo XXI Wieku, 2018
QUALITY ASSURANCE IN MOVING AND HANDLING EDUCATION: MYTH OR LEGEND Introduction.  The lack of quality assurance within moving and handling education leads to an inconsistency in training and practice. Aim.  This article discusses the implications for
Kevin Hares, Stephen Wanless
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

International Symposium on Spatial Data Handling (10th : 2002 : Ottawa, Canada)

, 2002
International Symposium on Spatial Data Handling (SDH), Ottawa, Canada, 9-12 July, 2002. In Advances in spatial data handling: 10th International Symposium on Spatial Data Handling, 2002, p.
Xia Li, Yeh, AGO, Li, X, Anthony Gar-On Yeh   +3 more
core   +1 more source

An Algorithm for Efficient Generation of Customized Priority Rules for Production Control in Project Manufacturing with Stochastic Job Processing Times

Algorithms, 2020
Project Planning and Control (PPC) problems with stochastic job processing times belong to the problem class of Stochastic Resource-Constrained Multi-Project Scheduling Problems (SRCMPSP).
Mathias Kühn, Michael Völker, Thorsten Schmidt   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Analysis of Normative Requirements and Technical Specifications of a Structural Design of the Mechanical Device Operating in the Amusement Industry

Acta Technica Jaurinensis
In current hectic times, people should be able to slow down and diversify their free time. Therefore, the contribution of the amusement industry should not be negligible but, on the contrary, should be seen as something where whole families can seek ...
Denis Molnár, Miroslav Blatnický, Ján Dižo, Sebastián Solčanský, Dávid Čierňava   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source