Results 71 to 80 of about 4,098,153 (330)

A summary of rotorcraft handling qualities research at NASA Ames Research Center [PDF]

open access: yes, 1984
The objectives of the rotorcraft handling qualities research program at Ames Research Center are twofold: (1) to develop basic handling qualities design criteria to permit cost effective design decisions to be made for helicopters, and (2) to obtain ...
Chen, R. T.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

ARCHING BEHAVIOUR OF COHESIVE POWDERS IN A PILOT-SCALE PLANE-FLOW SILO

open access: yesTASK Quarterly, 2003
The paper records some of the results and observations from a pilot scale plane-flow silo with a variable geometry hopper and a fully width slot outlet.
ROBERT J. BERRY   +2 more
doaj  

Analysis of Normative Requirements and Technical Specifications of a Structural Design of the Mechanical Device Operating in the Amusement Industry

open access: yesActa Technica Jaurinensis
In current hectic times, people should be able to slow down and diversify their free time. Therefore, the contribution of the amusement industry should not be negligible but, on the contrary, should be seen as something where whole families can seek ...
Denis Molnár   +4 more
doaj   +1 more source

Journal Staff [PDF]

open access: yes, 1959
This work presents the evaluation of an experiment on the relationship between driver performance and vehicle handling quantities. Both of them are instrumental quantities, however, the former are driver dependent, the latter are only vehicle dependent ...
Drugge, Lars   +2 more
core   +1 more source

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2

open access: yesDiabetologia, 2018
The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by ensuring that glucose is not lost in the urine.
C. Ghezzi, D. Loo, E. M. Wright
semanticscholar   +1 more source

The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific

open access: yesScientific Reports, 2020
Handling is a well-known source of stress to laboratory animals and can affect variability of results and even compromise animal welfare. The conventional tail handling in mice has been shown to induce aversion and anxiety-like behaviour. Recent findings
F. Sensini   +7 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

An Improved Method for Detecting Crane Wheel–Rail Faults Based on YOLOv8 and the Swin Transformer

open access: yesSensors
In the realm of special equipment, significant advancements have been achieved in fault detection. Nonetheless, faults originating in the equipment manifest with diverse morphological characteristics and varying scales.
Yunlong Li   +4 more
doaj   +1 more source

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