Results 61 to 70 of about 837,729 (288)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Advances in Mechanical EngineeringThe elastic deformation of the front subframe during vehicle traveling affects the vehicle handling stability. The static equilibrium equations of the suspension and subframe system and the kinematics equations of the three-degree-of-freedom vehicle are ...
Jin Gao, Mingyang Du
doaj +1 more source
Numerical Stability and Handling Studies of Three-Wheeled Vehicles Using ADAMS/Car
Applied SciencesThree-wheeled vehicles are gaining popularity in European and Asian cities due to their low cost, stability, maneuverability, and compact size. Among these, tilting vehicles facilitate cornering, maintain stability, and reduce centrifugal forces.
Katarzyna Stańko-Pająk +5 more
doaj +1 more source
Variable steering ratio design and handling stability research for steer-by-wire forklift
Advances in Mechanical Engineering, 2019 For the TFC35 steer-by-wire forklift, a linear 3-degree-of-freedom forklift model is given, which provides a verification model for variable steering ratio design. The concept of ideal steering ratio is expounded.
Junjie Huang, Benxian Xiao
doaj +1 more source
Automated Class Scheduling System
JPAIR, 2012 The study tested the functionality of Automated Class Scheduling System in terms of speed, data handling, accuracy, security, stability and adaptability in making class schedules.
Jeralyn M. Gamale +2 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Eliminating Network Protocol Vulnerabilities Through Abstraction and Systems Language Design
, 2013 Incorrect implementations of network protocol message specifications affect the stability, security, and cost of network system development. Most implementation defects fall into one of three categories of well defined message constraints.
Casey, C. Jasson +3 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source