Results 51 to 60 of about 63,333 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Tablet computers in assessing performance in a high stakes exam : opinion matters [PDF]

open access: yes, 2017
The authors would like to thank Dr Craig brown, University of Aberdeen for assistance with data analysis.Peer reviewedPublisher ...
Cleland, J.   +4 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Exploratory analysis on dictated handwriting samples

open access: yesJournal of Forensic Science and Medicine, 2019
Dictated handwriting samples are widely used in practice due to their simplicity, convenience, and practicality. However, dictation is typically listed as one of the many collection methods in textbooks and monographs, and there is usually no separate ...
Xuelin Gao, Yanling Wang
doaj   +1 more source

Construction and evaluation of classifiers for forensic document analysis

open access: yes, 2011
In this study we illustrate a statistical approach to questioned document examination. Specifically, we consider the construction of three classifiers that predict the writer of a sample document based on categorical data.
Davis, Linda J.   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Measuring Line Length

open access: yesArab Journal of Forensic Sciences & Forensic Medicine
The scientific methodology for forensic examination of handwriting is based on studying the individual handwriting features and characteristics that distinguish its writer from others.
Ahmed Saad Goher, Paolo Vaccarone
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

A Review of Multilingual Handwriting Analysis Techniques in Forensic Science

open access: yesJournal of Forensic Science and Medicine
Handwriting analysis is a crucial forensic tool used for identifying individuals, authenticating documents, and detecting forgeries in both civil and criminal investigations.
Ganti Skanda Priya   +2 more
doaj   +1 more source

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