Results 41 to 50 of about 4,932 (258)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
On the Mathematics of Mathematical Handwriting Recognition [PDF]
2010 12th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing, 2010 Abstract-Accurate computer recognition of handwritten mathematics offers to provide a natural interface for mathematical computing, document creation and collaboration. Mathematical handwriting, however, provides a number of challenges beyond what is required for the recognition of handwritten natural languages.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Applied Sciences, 2021 Handwriting verification is a biometric recognition field that identifies individuals’ unique characteristics contained in their handwriting. A single written character shows subtle differences depending on habits accumulated over time or the manner of ...
Kyung Won Jin, Eui Chul Lee
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Improved Handwritten Digit Recognition Using Convolutional Neural Networks (CNN)
Sensors, 2020 Traditional systems of handwriting recognition have relied on handcrafted features and a large amount of prior knowledge. Training an Optical character recognition (OCR) system based on these prerequisites is a challenging task.
Savita Ahlawat +4 more
doaj +1 more source
JOIV: International Journal on Informatics Visualization, 2023 Around 27 languages and more than 420 million people worldwide use Arabic letters. That makes the Arabic language one of the most used languages. However, the Arabic language has a challenge, namely the difference in letters based on their position ...
Siti Ummi Masruroh +4 more
doaj +1 more source