Results 191 to 200 of about 43,210 (256)

Therapeutic Modulation of Meningeal Lymphatics: A Systematic Review of Preclinical Evidence Across Neurological Disorders. [PDF]

Cell Mol Neurobiol
Kollarik S, Humer SK, Zurfluh CE, Gousopoulos E, Lindenblatt N.   +4 more
europepmc   +1 more source

Mechanical Strength: An Unrecognised Target in the Genetic Improvement of Crops

Plant Biotechnology Journal, EarlyView.
ABSTRACT Leaf angle (LA) is a crucial agronomic trait influencing planting density and crop yield. Previous research highlighted the importance of cellular variations in the ligular region for determining LA, but the underlying regulatory mechanisms remain unclear.
Qingbiao Shi, Qibin Wang, Guodong Wang, Yiduo An, Hengjia Yang, Qing Tao, Ying Xia, Zihao Jiao, Naiqian Li, Ran Gao, Junfen Li, Fanying Kong, Haisen Zhang, Pinghua Li, Mingyue Gou, Haiyang Wang, Bosheng Li, Gang Li   +17 more
wiley   +1 more source

Disrupting the TGF-β-regulated epithelial-mesenchymal transition, apoptotic and autophagic phenotypes of 3D glioblastoma spheroids via glycolytic inhibition. [PDF]

Explor Target Antitumor Ther
Payet-Desruisseaux M, Zgheib A, Danalache BA, Desjarlais M, Annabi B.   +4 more
europepmc   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Network Pharmacology Analysis and Experimental Study of Yinchen Against Neuroinflammation in Ischemic Stroke. [PDF]

Pharmaceuticals (Basel)
Guo M, Ma Y, Wang L, Ge R, Wang Y, Ma G, Du G, Li L.   +7 more
europepmc   +1 more source

Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing‐Based Breeding

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rice is the staple crop for more than half of the global population, and improving grain yield, grain quality, and stress resistance remain central goals of modern rice breeding. Among current precision breeding strategies, genome editing has created new opportunities for crop improvement, but its success depends heavily on the selection of ...
Wenhao Wu, Feng Jin, Huaxiang Xu, Ranran Liao, Zhongming Fang   +4 more
wiley   +1 more source

A HAZOP-based hazard identification model for urban gas accidents: Development and empirical validation. [PDF]

PLoS One
Tian B, Li H, Cui X, Hu Z, Zhou Z, Shi W.   +5 more
europepmc   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Frost heave behavior of coarse-grained materials for high-speed railways subgrade: experimental analysis and machine learning predictive modeling. [PDF]

Sci Rep
Li S, Wang K, Tian S, Xing W, Ling X, Tang L, Li G, Zhao W.   +7 more
europepmc   +1 more source

Drivers of Noncompliance With Vaccine Mandates—The Interplay Between Distrust, Rationality, Morality, and Social Motivation

Regulation &Governance, EarlyView.
ABSTRACT COVID‐19 amplified the issue of public resistance to government vaccination programs. Little attention has focused on people's moral reasons for noncompliance, which differ from—but often build upon—the epistemic claims they make about vaccine safety and efficacy, disease severity, and the trustworthiness of government. This study explores the
Katie Attwell, Hang Duong, Amy Morris, Leah Roberts, Mark Navin   +4 more
wiley   +1 more source