Results 161 to 170 of about 2,261 (229)

Modern History of Hansen's Disease in Korea. [PDF]

Infect Chemother, 2020
Chae GT.
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks

Clinical &Experimental Allergy, EarlyView.
In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Paula J. Busse, Teresa Caballero, Danny M. Cohn, Mar Guilarte, Henriette Farkas, Douglas H. Jones, Sorena Kiani‐Alikhan, Michael E. Manning, Marcus Maurer, Marc A. Riedl, Sinisa Savic, H. James Wedner, Patrick F. K. Yong, Andrea Zanichelli, Sally van Kooten, Matthew Iverson, Erik Hansen, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, William R. Lumry   +24 more
wiley   +1 more source

RIMOXCLAMIN: New therapeutic regimen for Hansen's Disease cure based on effective sensitivity recovery. [PDF]

Braz J Infect Dis
Frade MAC, Albertino GS, Lima FR, de Paula NA, Cinto FAC, Perecin FC, Westin A, Junior WM, Lugão HB.   +8 more
europepmc   +1 more source

Atypical Hansen's Disease Mimicking Xanthogranuloma: Role of Cytology.

J Cutan Aesthet Surg, 2023
Vijayvergiya G, Panwar H, Santosh T, Patra S, Joshi D, Asati DP, Kapoor N.   +6 more
europepmc   +1 more source

Spatial associations of Hansen's disease and schistosomiasis in endemic regions of Minas Gerais, Brazil. [PDF]

PLoS Negl Trop Dis
Stephens JL, Fraga LAO, Ferreira JA, De Mondesert L, Kitron U, Clennon JA, Fairley JK.   +6 more
europepmc   +1 more source

Multi‐angle, cross‐domain fusion strategy enhances automated insect identification and hierarchical categorization: a case study on assassin bugs (Hemiptera: Reduviidae)

Cladistics, EarlyView.
Abstract Automated insect identification systems hold significant value for biodiversity monitoring, pest management, citizen science initiatives and systematic studies, particularly in an era of declining expertise in insect taxonomy. However, current deep learning approaches often rely on standardized specimen photos from limited‐angles and ...
Xinkai Wang, Huaiyu Liu, Zhuo Chen, Yisheng Zhao, Yingqi Liu, Haoyang Xiong, Yuange Duan, Fang Song, Wanzhi Cai, Xuankun Li, Hu Li   +10 more
wiley   +1 more source

Perceived costs as drivers of wildlife management preferences in rural Tanzanian communities

Conservation Biology, EarlyView.
Abstract Effectively managing human–wildlife interactions is crucial for fostering coexistence on shared landscapes. Management options are most effective when aligned with the preferences of people directly affected by wildlife, yet little is known about how socioecological factors influence these preferences.
Christian Kiffner, Justin Raycraft, Reilly Becchina, Danielle Bettermann, Stephen Koester, Elana Kriegel, Kiana Lindsay, Edwin Maingo Ole, Emily Ramirez, Bryan Spizuco, Neil H. Carter   +10 more
wiley   +1 more source