Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome [PDF]
Viruses, 2022 Hantaan virus is the causative agent of hemorrhagic fever with renal syndrome (HFRS). The Hantaan virus strain, Korean hemorrhagic fever virus clone-5 (KHF5), causes weight loss and renal hemorrhage in laboratory mice.
Zhouoxing Wei +6 more
doaj +4 more sources
Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus [PDF]
Microorganisms, 2021 Ecological changes, population movements and increasing urbanization promote the expansion of hantaviruses, placing humans at high risk of virus transmission and consequent diseases.
Jennifer Mayor +2 more
doaj +6 more sources
Clinical Evaluation of a Vaccinia-Vectored Hantaan Virus Vaccine [PDF]
Journal of Medical Virology, 2000 We evaluated a vaccinia-vectored vaccine for hemorrhagic fever with renal syndrome in clinical trials. A Phase I dose-escalation study in 16 volunteers divided into four groups demonstrated that subcutaneous inoculation of approximately 107 plaque ...
Harrison, Stephen +4 more
core +7 more sources
Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax) in Korea [PDF]
Journal of Preventive Medicine and Public Health, 2019 The Ministry of Food and Drug Safety of Korea made an official announcement in March 2018 that the total number of inoculations of Hantaan virus vaccine (Hantavax®) would change from 3 to 4. Some aspects of this decision remain controversial.
Jong-Myon Bae
doaj +3 more sources
Structural characterization of the full-length Hantaan virus polymerase. [PDF]
PLoS PathogensHantaviridae are a family of segmented negative-sense RNA viruses that contain important human and animal pathogens. Hantaviridae contain a viral RNA-dependent RNA polymerase that replicates and transcribes the viral genome.
Jeremy R Keown +4 more
doaj +3 more sources
Development of an in-house dual RT-qPCR assay for detecting SFTSV and Hantaan virus simultaneously [PDF]
Biosafety and HealthGiven the overlapping endemic regions and clinical similarities between severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS), we developed a dual real‐time fluorescence‐based reverse transcription ...
Xiaoyu Xue +10 more
doaj +3 more sources
Plasma thrombomodulin is a valuable biomarker to predict the severity of hemorrhagic fever with renal syndrome caused by the Hantaan virus [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectivesThis study aimed to investigate the Thrombomodulin (TM) levels in patients who suffered hemorrhagic fever with renal syndrome (HFRS) of varying severities, and to evaluate the predictive properties of TM for the seriousness of HFRS, thereby ...
Han-Dong Zhao +8 more
doaj +3 more sources
The Hantaan Virus Glycoprotein Precursor Is Cleaved at the Conserved Pentapeptide WAASA [PDF]
Virology, 2001 The medium segment of the tripartite negative-stranded RNA genome of hantaviruses encodes for the predicted glycoprotein precursor GPC. We have demonstrated here the expression of the glycoprotein precursor of Hantaan virus following transfection of ...
Anheier, Bärbel +4 more
core +5 more sources
Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. [PDF]
PLoS Pathogens, 2016 Segmented negative strand RNA viruses of the arena-, bunya- and orthomyxovirus families uniquely carry out viral mRNA transcription by the cap-snatching mechanism.
Juan Reguera +6 more
doaj +4 more sources
Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication [PDF]
Nature Communications, 2023 Hantaviruses are causing life-threatening zoonotic infections in humans. Their tripartite negative-stranded RNA genome is replicated by the multi-functional viral RNA-dependent RNA-polymerase.
Quentin Durieux Trouilleton +4 more
doaj +2 more sources