Results 1 to 10 of about 1,691,113 (258)

Anti‐platelet factor 4/heparin antibodies in patients with Hantaan virus infection [PDF]

Research and Practice in Thrombosis and Haemostasis, 2022
Background Hemorrhagic fever with renal syndrome (HFRS) induced by Hantaan virus infection and heparin‐induced thrombocytopenia (HIT) are associated with symptoms such as thrombocytopenia and thrombosis.
Meng Wang, Chun‐mei Zhang, Ying Ma, Kang Tang, Xi‐yue Zhang, Xiao‐zhou Jia, Hai‐feng Hu, Ran Zhuang, Bo‐quan Jin, Yu‐si Zhang, Yun Zhang   +10 more
doaj   +4 more sources

Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus [PDF]

Microorganisms, 2021
Ecological changes, population movements and increasing urbanization promote the expansion of hantaviruses, placing humans at high risk of virus transmission and consequent diseases.
Jennifer Mayor, Olivier Engler, Sylvia Rothenberger   +2 more
doaj   +7 more sources

Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication [PDF]

Nature Communications, 2023
Hantaviruses are causing life-threatening zoonotic infections in humans. Their tripartite negative-stranded RNA genome is replicated by the multi-functional viral RNA-dependent RNA-polymerase.
Quentin Durieux Trouilleton, Sergio Barata-García, Benoît Arragain, Juan Reguera, Hélène Malet   +4 more
doaj   +3 more sources

LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation. [PDF]

Front Microbiol, 2022
As the global prototypical zoonotic hantavirus, Hantaan virus (HTNV) is prevalent in Asia and is the leading causative agent of severe hemorrhagic fever with renal syndrome (HFRS), which has profound morbidity and mortality.
Yang Y, Li M, Ma Y, Ye W, Si Y, Zheng X, Liu H, Cheng L, Zhang L, Zhang H, Zhang X, Lei Y, Shen L, Zhang F, Ma H.   +14 more
europepmc   +4 more sources

An algal lectin griffithsin inhibits Hantaan virus infection in vitro and in vivo. [PDF]

Front Cell Infect Microbiol, 2022
Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections.
Zhao Y, Zhao N, Cai Y, Zhang H, Li J, Liu J, Ye C, Wang Y, Dang Y, Li W, Liu H, Zhang L, Li Y, Zhang L, Cheng L, Dong Y, Xu Z, Lei Y, Lu L, Wang Y, Ye W, Zhang F.   +21 more
europepmc   +4 more sources

Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome [PDF]

Viruses, 2022
Hantaan virus is the causative agent of hemorrhagic fever with renal syndrome (HFRS). The Hantaan virus strain, Korean hemorrhagic fever virus clone-5 (KHF5), causes weight loss and renal hemorrhage in laboratory mice.
Zhouoxing Wei, Kenta Shimizu, Rakiiya S. Sarii, Devinda S. Muthusinghe, Sithumini M. W. Lokupathirage, Junko Nio-Kobayashi, Kumiko Yoshimatsu   +6 more
doaj   +3 more sources

A comprehensive investigation of Glycoprotein-based nucleic acid vaccines for Hantaan Virus. [PDF]

NPJ Vaccines
Hemorrhagic fever with renal syndrome (HFRS) occurs throughout Eurasia with considerable morbidity and mortality. Currently, the absence of specific treatments or effective antiviral drugs for hantavirus infection makes developing safe and effective ...
Zhang J, Zhang J, Wang Y, Sun Y, Wang Y, Wang Y, Yang D, Qiao X, Liu X, Ding J, Zhang X, Zhang W, Wang Z, Hu C, Han C, Liu T, Yang S, Sun Y, Cheng L, Jiang D, Yang K.   +20 more
europepmc   +3 more sources

Simultaneous rapid detection of Hantaan virus and Seoul virus using RT-LAMP in rats [PDF]

PeerJ, 2019
Background Hemorrhagic fever with renal syndrome is in most cases caused by the Hantaan virus (HTNV) and Seoul virus (SEOV). To develop and apply reverse transcription loop-mediated isothermal amplification (RT-LAMP) to detect HTNV and SEOV ...
Xin Sui, Xu Zhang, Dongliang Fei, Zhen Zhang, Mingxiao Ma   +4 more
doaj   +5 more sources

Increased CD4⁺CD8⁺ Double Positive T Cells during Hantaan Virus Infection [PDF]

Viruses, 2022
Hantaan virus (HTNV) infection causes an epidemic of hemorrhagic fever with renal syndrome (HFRS) mainly in Asia. It is well known that T cells mediated anti-viral immune response.
Huiyuan Zhang, Yazhen Wang, Ying Ma, Kang Tang, Chunmei Zhang, Meng Wang, Xiyue Zhang, Manling Xue, Xiaozhou Jia, Haifeng Hu, Na Li, Ran Zhuang, Boquan Jin, Lihua Chen, Yun Zhang, Yusi Zhang   +15 more
doaj   +3 more sources

Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen [PDF]

mBio, 2021
Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents higher-order tetrameric assemblies of two glycoproteins, Gn and Gc, which are responsible for ...
Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores   +12 more
doaj   +3 more sources