Anti‐platelet factor 4/heparin antibodies in patients with Hantaan virus infection [PDF]
Research and Practice in Thrombosis and Haemostasis, 2022 Background Hemorrhagic fever with renal syndrome (HFRS) induced by Hantaan virus infection and heparin‐induced thrombocytopenia (HIT) are associated with symptoms such as thrombocytopenia and thrombosis.
Meng Wang +10 more
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Structural characterization of the full-length Hantaan virus polymerase. [PDF]
PLoS PathogensHantaviridae are a family of segmented negative-sense RNA viruses that contain important human and animal pathogens. Hantaviridae contain a viral RNA-dependent RNA polymerase that replicates and transcribes the viral genome.
Jeremy R Keown +4 more
doaj +3 more sources
Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus [PDF]
Microorganisms, 2021 Ecological changes, population movements and increasing urbanization promote the expansion of hantaviruses, placing humans at high risk of virus transmission and consequent diseases.
Jennifer Mayor +2 more
doaj +6 more sources
Development of an in-house dual RT-qPCR assay for detecting SFTSV and Hantaan virus simultaneously [PDF]
Biosafety and HealthGiven the overlapping endemic regions and clinical similarities between severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS), we developed a dual real‐time fluorescence‐based reverse transcription ...
Xiaoyu Xue +10 more
doaj +3 more sources
Simultaneous rapid detection of Hantaan virus and Seoul virus using RT-LAMP in rats [PDF]
PeerJ, 2019 Background Hemorrhagic fever with renal syndrome is in most cases caused by the Hantaan virus (HTNV) and Seoul virus (SEOV). To develop and apply reverse transcription loop-mediated isothermal amplification (RT-LAMP) to detect HTNV and SEOV ...
Xin Sui +4 more
doaj +4 more sources
Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication [PDF]
Nature Communications, 2023 Hantaviruses are causing life-threatening zoonotic infections in humans. Their tripartite negative-stranded RNA genome is replicated by the multi-functional viral RNA-dependent RNA-polymerase.
Quentin Durieux Trouilleton +4 more
doaj +2 more sources
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome [PDF]
Viruses, 2022 Hantaan virus is the causative agent of hemorrhagic fever with renal syndrome (HFRS). The Hantaan virus strain, Korean hemorrhagic fever virus clone-5 (KHF5), causes weight loss and renal hemorrhage in laboratory mice.
Zhouoxing Wei +6 more
doaj +2 more sources
Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen [PDF]
mBio, 2021 Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents higher-order tetrameric assemblies of two glycoproteins, Gn and Gc, which are responsible for ...
Ilona Rissanen +12 more
doaj +2 more sources
Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax) in Korea [PDF]
Journal of Preventive Medicine and Public Health, 2019 The Ministry of Food and Drug Safety of Korea made an official announcement in March 2018 that the total number of inoculations of Hantaan virus vaccine (Hantavax®) would change from 3 to 4. Some aspects of this decision remain controversial.
Jong-Myon Bae
doaj +2 more sources
Increased CD4+CD8+ Double Positive T Cells during Hantaan Virus Infection [PDF]
Viruses, 2022 Hantaan virus (HTNV) infection causes an epidemic of hemorrhagic fever with renal syndrome (HFRS) mainly in Asia. It is well known that T cells mediated anti-viral immune response.
Huiyuan Zhang +15 more
doaj +2 more sources