Hantaan virus is a dangerous human pathogen whose segmented negative-stranded RNA genome is replicated and transcribed by a virally-encoded multi-functional polymerase.
Quentin Durieux Trouilleton+4 more
doaj +1 more source
Pre-Clinical Studies of Inactivated Polivalent Vaccine Against Hemorrhagic Fever with Renal Syndrome
Relevance. Hemorrhagic fever with renal syndrome (HFRS) is a non-transmissible viral zoonosis widespread in Eurasia, and in Russia it occupies a leading position among zoonotic viral infections and one of the first places among all natural focal human ...
A. A. Sinyugina+7 more
doaj +1 more source
Hantavirus Pulmonary Syndrome: CD8+and CD4+Cytotoxic T Lymphocytes to Epitopes on Sin Nombre Virus Nucleocapsid Protein Isolated during Acute Illness [PDF]
In 1993 a number of cases of unexplained adult respiratory syndrome occurred in the southwestern United States. The illness was characterized by a prodrome of fever, myalgia, and other symptoms followed by the rapid onset of a capillary leak syndrome ...
Cruz, John+7 more
core +1 more source
Examining both long‐term and short‐term effects can enhance the precision and reliability of time series analysis. This study aimed to delve into the asymmetric effects of weather conditions on hemorrhagic fever with renal syndrome (HFRS) in the long and short terms and build a forecasting system.
Yongbin Wang+6 more
wiley +1 more source
Methods of Repairing Virus Infected Files, A TRIZ based Analysis [PDF]
Most viruses are capable of fixing up the first few bytes and repair the original program because they have to return the control back to the infected program. This fact is used by a heuristic cleaner to clean the infected file. As the virus knows how to repair the it uses the same virus to repair the infected file.
arxiv
Understanding the fate of corona virus transmission using a simple model [PDF]
We propose a simple model for understanding the kinetics of corona virus transmission. Our model assume spreading of corona virus can happen from one to another only, if someone without enough protection comes close contact to a person carrying the corona virus.
arxiv
Hantavirus glycoprotein GN in virion assembly and regulation of interferon response [PDF]
Hantaviruses have a tri-segmented negative-stranded RNA genome. The S segment encodes the nucleocapsid protein (N), M segment two glycoproteins, Gn and Gc, and the L segment the RNA polymerase.
Wang, Hao
core
Coronavirus SARS-CoV-2: Analysis of subgenomic mRNA transcription, 3CLpro and PL2pro protease cleavage sites and protein synthesis [PDF]
Coronaviruses have recently caused world-wide severe outbreaks: SARS (Severe Acute Respiratory Syndrome) in 2002 and MERS (Middle-East Respiratory Syndrome) in 2012. At the end of 2019, a new coronavirus outbreak appeared in Wuhan (China) seafood market as first focus of infection, becoming a pandemics in 2020, spreading mainly into Europe and Asia ...
arxiv
Ribavirin Causes Error Catastrophe during Hantaan Virus Replication [PDF]
ABSTRACT Except for ribavirin, no other antiviral drugs for treating hantaviral diseases have been identified. It is well established that ribavirin will inhibit the production of infectious Hantaan virus (HTNV); however, its mechanism of action is unknown.
Connie S. Schmaljohn+3 more
openaire +3 more sources
A small molecule drug candidate targeting SARS-CoV-2 main protease [PDF]
A new coronavirus identified as SARS-CoV-2 virus has brought the world to a state of crisis, causing a major pandemic, claiming more than 433,000 lives and instigating major financial damage to the global economy. Despite current efforts, developing safe and effective treatments remains a major challenge.
arxiv