Results 11 to 20 of about 8,666 (240)

Hantaan Virus (HTNV) Human Infection on Jeju Island, South Korea: Unique Phylogeny and Epidemiology of HTNV. [PDF]

J Med Virol
Journal of Medical Virology, Volume 97, Issue 3, March 2025.
Kim M, Heo ST, Kang SY, Bae E, Yoo JR, Song YJ, Wiley M, Wiley JD, Nguyen HC, Letizia AG, Lee KH.   +10 more
europepmc   +3 more sources

Hantaan virus glycoprotein Gc induces NEDD4-dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation. [PDF]

FASEB J
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Lu S, Chen S, Zhang Y, Mou X, Li M, Zhu S, Chen X, Strandin TM, Jiang Y, Xiang Z, Liu Y, Xiong H, Guo D, Chen L, Li Y, Hou W, Luo F.   +16 more
europepmc   +3 more sources

Anti‐platelet factor 4/heparin antibodies in patients with Hantaan virus infection [PDF]

Research and Practice in Thrombosis and Haemostasis, 2022
Background Hemorrhagic fever with renal syndrome (HFRS) induced by Hantaan virus infection and heparin‐induced thrombocytopenia (HIT) are associated with symptoms such as thrombocytopenia and thrombosis.
Meng Wang, Chun‐mei Zhang, Ying Ma, Kang Tang, Xi‐yue Zhang, Xiao‐zhou Jia, Hai‐feng Hu, Ran Zhuang, Bo‐quan Jin, Yu‐si Zhang, Yun Zhang   +10 more
doaj   +2 more sources

Structural Characterization of the Full-length Hantaan Virus Polymerase

PLOS Pathogens, 2023
AbstractHantaviridaeare a family of segmented negative-sense RNA viruses that contains important human and animal pathogens including Andes orthohantavirus and Hantaan orthohantavirus.Hantaviridaecontain a viral RNA-dependent RNA polymerase that replicates and transcribes the viral genome in the cytoplasm of infected cells.
Keown JR, Carrique L, Nilsson-Payant B, Fodor E, Grimes JM.   +4 more
europepmc   +4 more sources

Acute Appendicitis Associated with Hantaan Virus Infection. [PDF]

Am J Trop Med Hyg, 2021
ABSTRACT. Hantaviruses are Bunyaviridae viruses that cause hemorrhagic fever with renal syndrome. Appendicitis caused by Hantaan virus has not been reported previously. An 81-year-old man who underwent laparoscopic appendectomy for suspected appendicitis based on abdominal pain, fever, hypotension, and computed tomography findings. Based on a suspicion
Lim SC, Lee YM, Kim CM, Yun NR, Kim DM.
europepmc   +4 more sources

Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen [PDF]

mBio, 2021
Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents higher-order tetrameric assemblies of two glycoproteins, Gn and Gc, which are responsible for ...
Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores   +12 more
doaj   +2 more sources

Cell Fusion Activities of Hantaan Virus Envelope Glycoproteins [PDF]

Journal of Virology, 2004
ABSTRACT Hantaan virus (HTNV)-infected Vero E6 cells undergo cell fusion with both infected and uninfected cells under low-pH conditions. Flow cytometry and fluorescence microscopy of HTNV-infected Vero E6 cells showed that envelope glycoproteins (GPs) were located both on the cell surface and in the cytoplasm.
Kumiko Yoshimatsu, Megumi Okumura, Byoung-Hee Lee, Michiko Ogino, Hideki Ebihara, Koichi Araki, Jiro Arikawa   +6 more
openaire   +4 more sources

Increased CD4⁺CD8⁺ Double Positive T Cells during Hantaan Virus Infection [PDF]

Viruses, 2022
Hantaan virus (HTNV) infection causes an epidemic of hemorrhagic fever with renal syndrome (HFRS) mainly in Asia. It is well known that T cells mediated anti-viral immune response.
Huiyuan Zhang, Yazhen Wang, Ying Ma, Kang Tang, Chunmei Zhang, Meng Wang, Xiyue Zhang, Manling Xue, Xiaozhou Jia, Haifeng Hu, Na Li, Ran Zhuang, Boquan Jin, Lihua Chen, Yun Zhang, Yusi Zhang   +15 more
doaj   +2 more sources

Edging on Mutational Bias, Induced Natural Selection From Host and Natural Reservoirs Predominates Codon Usage Evolution in Hantaan Virus [PDF]

Frontiers in Microbiology, 2021
The molecular evolutionary dynamics that shape hantaviruses’ evolution are poorly understood even now, besides the contribution of virus-host interaction to their evolution remains an open question.
Galal Ata, Hao Wang, Haoxiang Bai, Xiaoting Yao, Shiheng Tao   +4 more
doaj   +2 more sources

Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus

Journal of General Virology, 2008
To gain further insight into the molecular epidemiology of Hantaan virus (HTNV) in Guizhou, China, rodents were captured in this region in 2004 and 2005. In addition, serum samples were collected from four patients. Ten hantaviruses were isolated successfully in cell culture from four humans, two Apodemus agrarius, three Rattus norvegicus and one ...
Guo-Dong Ren, Zhao-xiao Wang, Yang Zou, Yang Zou, Zhen F. Fu, Zheng-Xiu Duan, Ming-Hui Li, Yong-Zhen Zhang, Dingming Wang, Jing Hu, Alexander Plyusnin   +10 more
openaire   +3 more sources