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Maturation of hantaan virus glycoproteins G1 and G2
Virology, 1992Hantaan virus-infected Vero E6 cell lysates were used for immunoprecipitation with monoclonal antibodies against glycoprotein G1 (MAbG1) or G2 (MAbG2). When cell lysates were prepared with buffer containing nonionic detergent, both G1 and G2 glycoproteins were precipitated with either MAbG1 or MAbG2.
Kathryn E. Wright +2 more
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Coding strategy of the S genome segment of Hantaan virus
Virology, 1986Hantaan virus is the type species of the recently recognized Hantavirus genus of Bunyaviridae. The small (S) RNA segment of the negative-sense, tripartite genome was molecularly cloned and the nucleotide sequence was determined. The RNA sequence derived from the cDNA copy was found to contain 1696 nucleotides.
Joel M. Dalrymple +3 more
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Identification of hantaan virus messenger RNA species
Virus Research, 1985Abstract : The coding strategy of Hantaan (HTN) virus was examined by translation of intracellular viral RNA species and by hybridization of cDNA probes to infected cell lysates. A polypeptide with a molecular weight of approximately 50 000 was generated in rabbit reticulocyte lysates. This polypeptide originated from a message which correspond in size
Connie S. Schmaljohn +2 more
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Ribavirin Therapy for Hantaan Virus Infection in Suckling Mice
Journal of Infectious Diseases, 1986We recently reported that ribavirin inhibited Hantaan virus (HV) replication in vitro. In the present study, we used the HV suckling mouse model to evaluate the efficacy of treatment with various doses of ribavirin. Beginning on day 10, untreated animals, infected with ten times the amount of HV (strain 76/118) required to kill 50% of the animals, lost
Gum Ryong Kim +3 more
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Pathogenesis of experimental Hantaan virus infection in laboratory rats
Archives of Virology, 1986Weanling Fischer rats inoculated intramuscularly with Hantaan virus (strain 76-118) developed subclinical infections characterized by transient viremia and shedding of virus in saliva, persistence of virus in lung, pancreas, spleen and liver, and development of fluorescent and neutralizing antibodies in serum with immune complex deposition in lung ...
R. Yanagihara +3 more
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A Scottish case of nephropathy due to Hantaan virus infection
Journal of Infection, 1985An illness characterised by acute renal failure, fever, conjunctivitis and a macular erythematous centrifugal rash is described in a Scot who had not recently travelled abroad. There was serological evidence that the illness was due to Hantaan or a closely related virus.
E. Walker +3 more
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Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants
Journal of Virology, 1990Baculovirus and vaccinia virus vectors were used to express the small (S) and medium (M) genome segments of Hantaan virus. Expression of the complete S or M segments yielded proteins electrophoretically indistinguishable from Hantaan virus nucleocapsid protein or envelope glycoproteins (G1 and G2), and expression of portions of the M segment, encoding ...
Joel M. Dalrymple +3 more
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1996
Hantaviruses were first recognized as a cause of serious disease in 1951 when 3000 United Nations troops in Korea developed an illness characterized by fever, headache, back and abdominal pain, with haemorrhage in many cases. This disease had a case-fatality of 5–10% and was named Korean haemorrhagic fever [18].
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Hantaviruses were first recognized as a cause of serious disease in 1951 when 3000 United Nations troops in Korea developed an illness characterized by fever, headache, back and abdominal pain, with haemorrhage in many cases. This disease had a case-fatality of 5–10% and was named Korean haemorrhagic fever [18].
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Expression strategy of the M genome segment of Hantaan virus
Virus Research, 1994The medium (M) genome segment of Hantaan virus encodes the envelope glycoproteins, G1 and G2, in a continuous open reading frame with a gene order of 5'-G1-G2-3' with respect to the virus-complementary sense RNA. Because potential translation initiation codons and amino acids constituting typical signal sequences precede both the G1 and G2 genes, we ...
Connie S. Schmaljohn, Kurt I. Kamrud
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Serological Evidence of Hantaan Virus Infection in the United States
The American Journal of Tropical Medicine and Hygiene, 1985We found low titers of fluorescent antibodies against Hantaan virus, the etiologic agent of Korean hemorrhagic fever, in sera from 7 of 1,035 patients with febrile illnesses of unknown origin and from 6 of 664 blood donors in the United States. All but 1 of these individuals possessed neutralizing antibodies against Hantaan virus.
Chin Ct +9 more
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