Results 41 to 50 of about 4,807 (202)

MultiPrime: A reliable and efficient tool for targeted next‐generation sequencing

iMeta, Volume 2, Issue 4, November 2023., 2023
This study introduces multiPrime, a novel tool tailored for the wide‐ranging detection of target sequences through targeted next‐generation sequencing (tNGS). By integrating degenerate primer design principles with effective mismatch handling, multiPrime demonstrates enhanced precision and specificity in the identification of diverse sequence types ...
Han Xia, Zhe Zhang, Chen Luo, Kangfei Wei, Xuming Li, Xiyu Mu, Meilin Duan, Chuanlong Zhu, Luyi Jin, Xiaoqing He, Lingjie Tang, Long Hu, Yuanlin Guan, David C. C. Lam, Junbo Yang   +14 more
wiley   +1 more source

Arbidol: The current demand, strategies, and antiviral mechanisms

Immunity, Inflammation and Disease, Volume 11, Issue 8, August 2023., 2023
In this study, we review the structure of influenza virus, as well as the etiology, epidemiology, and pathophysiology of influenza virus. We describe the process of virus infection and summarize the current antiviral strategies and the reported antiviral mechanisms of ARB; these might be conducive to the discovery and development of novel antiviral ...
Yue Kang, Yin Shi, Silu Xu
wiley   +1 more source

High C‐reactive protein to lymphocyte ratio predicts mortality outcomes of patients with severe fever with thrombocytopenia syndrome: A multicenter study in China

Journal of Medical Virology, Volume 95, Issue 2, February 2023., 2023
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a life‐threatening infectious disease caused by the SFTS virus (SFTSV). This study aimed to evaluate the predictive power of C‐reactive protein to lymphocyte ratio (CLR) and establish an early‐warning model for SFTS mortality.
Fang Qian, Wei Zhou, Yuanni Liu, Ziruo Ge, Jianming Lai, Zhenghua Zhao, Yang Feng, Ling Lin, Yi Shen, Zhonglu Zhang, Wei Zhang, Tianli Fan, Yongxiang Zhao, Zhihai Chen   +13 more
wiley   +1 more source

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5

Cell Reports, 2019
Summary: Cytotoxic lymphocytes normally kill virus-infected cells by apoptosis induction. Cytotoxic granule-dependent apoptosis induction engages the intrinsic apoptosis pathway, whereas death receptor (DR)-dependent apoptosis triggers the extrinsic ...
Carles Solà-Riera, Shawon Gupta, Kimia T. Maleki, Patricia González-Rodriguez, Dalel Saidi, Christine L. Zimmer, Sindhu Vangeti, Laura Rivino, Yee-Sin Leo, David Chien Lye, Paul A. MacAry, Clas Ahlm, Anna Smed-Sörensen, Bertrand Joseph, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström   +16 more
doaj   +1 more source

EXPERIENCE IN DECONTAMINATION OF VIRAL STRAINS FROM MYCOPLASMAS

Ветеринарная патология, 2020
Mycoplasma contamination is a serious problem for the production of biologics in the veterinary and biopharmacological industries, as well as for research laboratories.
O. A. Leonovich, A. A. Ishmukhametov, T. K. Dzagurova   +2 more
doaj   +1 more source

Transmission of Haemorrhagic Fever with Renal Syndrome in China and the Role of Climate Factors: A Review

International Journal of Infectious Diseases, 2015
Haemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease that poses a serious public health threat in China. HFRS is caused by hantaviruses, mainly Seoul virus in urban areas and Hantaan virus in agricultural areas.
Alana Hansen, Scott Cameron, Qiyong Liu, Yehuan Sun, Philip Weinstein, Craig Williams, Gil-Soo Han, Peng Bi   +7 more
doaj   +1 more source

Hemorrhagic Fever with Renal Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Emerging Infectious Diseases, 2002
Hemophagocytic lymphohistiocytosis--which is associated with a variety of infections, malignant neoplasms, autoimmune diseases, and immunodeficiencies--is an uncommon syndrome with a rapidly fatal outcome.
Je-Jung Lee, Ik-Joo Chung, Dong-Hyeon Shin, Sang-Hee Cho, Duck Cho, Dong-Wook Ryang, Ali S. Khan, Hyeoung-Joon Kim   +7 more
doaj   +1 more source

Rescue of hantaan virus minigenomes

Virology, 2003
Hantavirus infections are a major public health concern worldwide. Their widespread geographical distribution and their ability to produce serious, often fatal, human disease underline the need for a system that allows manipulation of these viruses. We describe here the first successful establishment of a reverse genetics technology for Hantaan virus ...
Flick, Kirsten, Hooper, Jay W., Schmaljohn, Connie S., Pettersson, Ralf F., Feldmann, Heinz, Flick, Ramon   +5 more
openaire   +2 more sources

Ribavirin Causes Error Catastrophe during Hantaan Virus Replication [PDF]

Journal of Virology, 2003
ABSTRACT Except for ribavirin, no other antiviral drugs for treating hantaviral diseases have been identified. It is well established that ribavirin will inhibit the production of infectious Hantaan virus (HTNV); however, its mechanism of action is unknown.
William E, Severson, Connie S, Schmaljohn, Ali, Javadian, Colleen B, Jonsson   +3 more
openaire   +2 more sources

An HFman Probe-Based Multiplex Reverse Transcription Loop-Mediated Isothermal Amplification Assay for Simultaneous Detection of Hantaan and Seoul Viruses

Diagnostics, 2022
Hantaviruses are zoonotic pathogens that are widely distributed worldwide. Hantaan virus (HTNV) and Seoul virus (SEOV) are two most common hantaviruses that infect humans and cause hemorrhagic fever with renal syndrome (HFRS).
Yi Zeng, Yun Feng, Yongjuan Zhao, Xiaoling Zhang, Lifen Yang, Juan Wang, Zihou Gao, Chiyu Zhang   +7 more
doaj   +1 more source