Results 41 to 50 of about 8,666 (240)

Clinical and etiological characteristics of severe hemorrhagic fever caused by coinfection of hantaan orthohantavirus and severe fever with thrombocytopenia syndrome virus

Journal of Medical Virology, Volume 96, Issue 9, September 2024.
Abstract Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) usually have different infection routes, and coinfection is relatively rare. This study examines the clinical and etiological characteristics of coinfection by these two pathogens to provide important references for clinical diagnosis and ...
Jiang Feng, Yongxiang Zhao, Ruihao Peng, Ya Wen, Yudan Bi, Yichen Zhou, Yao Chen, Hua Deng, Xiaohu Han, Zeliang Chen   +9 more
openalex   +2 more sources

Synthesis and Antiviral Activity of Camphene Derivatives against Different Types of Viruses

Molecules, 2021
To date, the ‘one bug-one drug’ approach to antiviral drug development cannot effectively respond to the constant threat posed by an increasing diversity of viruses causing outbreaks of viral infections that turn out to be pathogenic for humans ...
Anastasiya S. Sokolova, Valentina P. Putilova, Olga I. Yarovaya, Anastasiya V. Zybkina, Ekaterina D. Mordvinova, Anna V. Zaykovskaya, Dmitriy N. Shcherbakov, Iana R. Orshanskaya, Ekaterina O. Sinegubova, Iana L. Esaulkova, Sophia S. Borisevich, Nikolay I. Bormotov, Larisa N. Shishkina, Vladimir V. Zarubaev, Oleg V. Pyankov, Rinat A. Maksyutov, Nariman F. Salakhutdinov   +16 more
doaj   +1 more source

Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine

Frontiers in Cellular and Infection Microbiology, 2020
Hemorrhagic fever with renal syndrome (HFRS) is the most common natural focal disease in the Russian Federation with about 6–12 thousand cases annually.
Tamara K. Dzagurova, Alexandra A. Siniugina, Aidar A. Ishmukhametov, Aidar A. Ishmukhametov, Maria S. Egorova, Svetlana S. Kurashova, Maria V. Balovneva, Andrey A. Deviatkin, Petr E. Tkachenko, Oksana A. Leonovich, Evgeny A. Tkachenko   +10 more
doaj   +1 more source

MultiPrime: A reliable and efficient tool for targeted next‐generation sequencing

iMeta, Volume 2, Issue 4, November 2023., 2023
This study introduces multiPrime, a novel tool tailored for the wide‐ranging detection of target sequences through targeted next‐generation sequencing (tNGS). By integrating degenerate primer design principles with effective mismatch handling, multiPrime demonstrates enhanced precision and specificity in the identification of diverse sequence types ...
Han Xia, Zhe Zhang, Chen Luo, Kangfei Wei, Xuming Li, Xiyu Mu, Meilin Duan, Chuanlong Zhu, Luyi Jin, Xiaoqing He, Lingjie Tang, Long Hu, Yuanlin Guan, David C. C. Lam, Junbo Yang   +14 more
wiley   +1 more source

Arbidol: The current demand, strategies, and antiviral mechanisms

Immunity, Inflammation and Disease, Volume 11, Issue 8, August 2023., 2023
In this study, we review the structure of influenza virus, as well as the etiology, epidemiology, and pathophysiology of influenza virus. We describe the process of virus infection and summarize the current antiviral strategies and the reported antiviral mechanisms of ARB; these might be conducive to the discovery and development of novel antiviral ...
Yue Kang, Yin Shi, Silu Xu
wiley   +1 more source

Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006–2014

Emerging Infectious Diseases, 2016
Analysis of hemorrhagic fever with renal syndrome cases in Zibo City, China, during 2006–2014 showed that it occurred year-round. Peaks in spring and fall/winter were caused by Hantaan and Seoul viruses, respectively.
Ling Wang, Tao Wang, Feng Cui, Shen-Yong Zhai, Ling Zhang, Shu-Xia Yang, Zhi-Qiang Wang, Xue-Jie Yu   +7 more
doaj   +1 more source

Bacterial Expression of Neutralizing Mouse Monoclonal Antibody Fab Fragments to Hantaan Virus [PDF]

, 1996
We amplified by polymerase chain reaction the heavy and light chain antibody genes of two mouse hybridomas secreting neutralizing monoclonal antibodies (MAbs) to the G1 or G2 envelope proteins of Hantaan virus, cloned them into the phagemid vector pComb3,
CHU, YONG-KYU, LIANG, MIFANG, SCHMALJOHN, CONNIE   +2 more
core   +1 more source

High C‐reactive protein to lymphocyte ratio predicts mortality outcomes of patients with severe fever with thrombocytopenia syndrome: A multicenter study in China

Journal of Medical Virology, Volume 95, Issue 2, February 2023., 2023
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is a life‐threatening infectious disease caused by the SFTS virus (SFTSV). This study aimed to evaluate the predictive power of C‐reactive protein to lymphocyte ratio (CLR) and establish an early‐warning model for SFTS mortality.
Fang Qian, Wei Zhou, Yuanni Liu, Ziruo Ge, Jianming Lai, Zhenghua Zhao, Yang Feng, Ling Lin, Yi Shen, Zhonglu Zhang, Wei Zhang, Tianli Fan, Yongxiang Zhao, Zhihai Chen   +13 more
wiley   +1 more source

HTNV infection of CD8+ T cells is associated with disease progression in HFRS patients

Communications Biology, 2021
Rongrong Liu et al. find that Hantaan virus, a common cause of hemorrhagic fever with renal syndrome (HFRS) in China, can infect CD8+ T cells and that these cells can support the full viral replication cycle.
Rongrong Liu, Ruixue Ma, Ziyu Liu, Haifeng Hu, Jiayi Shu, Peizhen Hu, Junjun Kang, Yusi Zhang, Mingwei Han, Xiaoxiao Zhang, Yiting Zheng, Qikang Ying, Shiyuan Hou, Wenqiu Wang, Fang Wang, Ning Cheng, Yan Zhuang, Jianqi Lian, Xia Jin, Xingan Wu   +19 more
doaj   +1 more source

Hantaan virus infection of human endothelial cells [PDF]

Journal of Virology, 1992
The primary pathophysiologic finding of the viral disease known as Korean hemorrhagic fever, the etiological agent of which is Hantaan virus (HTV), is vascular instability. To investigate whether HTV was able to infect cells derived from human vascular tissue and alter their behavior, we infected in vitro primary adult human endothelial cells from ...
Michael Pensiero, John Hay, J B Sharefkin, Carl W. Dieffenbach   +3 more
openaire   +3 more sources