Results 81 to 90 of about 4,807 (202)

A Multi-Valent Hantavirus Vaccine Based on Recombinant Modified Vaccinia Ankara Reduces Viral Load in a Mouse Infection Model

Vaccines
Background: Old World orthohantaviruses are the aetiological agent of Haemorrhagic Fever with Renal Syndrome (HFRS) disease. Worldwide, the two most prominent pathogens of HFRS are Seoul orthohantavirus (SEOV) and Hantaan orthohantavirus (HTNV). There is
Marilyn Aram, Victoria Graham, Emma Kennedy, Emma Rayner, Roger Hewson, Stuart Dowall   +5 more
doaj   +1 more source

Long‐ and Short‐Run Asymmetric Effects of Meteorological Parameters on Hemorrhagic Fever with Renal Syndrome in Heilongjiang: A Population‐Based Retrospective Study

Transboundary and Emerging Diseases, Volume 2024, Issue 1, 2024.
Examining both long‐term and short‐term effects can enhance the precision and reliability of time series analysis. This study aimed to delve into the asymmetric effects of weather conditions on hemorrhagic fever with renal syndrome (HFRS) in the long and short terms and build a forecasting system.
Yongbin Wang, Bingjie Zhang, Chenlu Xue, Peiping Zhou, Xinwen Dong, Chunjie Xu, Daniel Diaz   +6 more
wiley   +1 more source

Hantaan Virus Persistently Infects Marmoset B-Lymphoblastoid Cell Line.

Journal of Veterinary Medical Science, 1995
To investigate lymphoid cell Hantavirus (HV) interaction, we examined the replication of the HV strains, Hantaan 76-118 (HTN), SR-11, and B-1 with the B95a, LYM-1, CGM1, JM, Jurkat, MOLT-4, AT(L)5KY, BW5147, L1210, and Vero/E6 cells. HV-growth was determined by immunofluorescence and focus-forming assays.
K, Ohsawa, Y, Watanabe, H, Sato
openaire   +3 more sources

Exploring the Genetic Diversity and Molecular Evolution of Seoul and Hantaan Orthohantaviruses

Viruses
Seoul (SEOV) and Hantaan (HTNV) orthohantaviruses are significant zoonotic pathogens responsible for hemorrhagic fever with renal syndrome. Here, we investigated the molecular evolution of SEOV and HTNV through phylogenetic and bioinformatic analyses ...
Atanas V. Demirev, Sangyi Lee, Sejik Park, Hyunbeen Kim, Seunghye Cho, Kyuyoung Lee, Kisoon Kim, Jin-Won Song, Man-Seong Park, Jin Il Kim   +9 more
doaj   +1 more source

GBP1, an interferon‐inducible GTPase, inhibits Hantaan viral entry by restricting clathrin‐mediated endocytosis

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Morgan Brisse, Hinh Ly
wiley   +1 more source

Clinical evaluation of a vaccinia-vectored Hantaan virus vaccine

Journal of Medical Virology, 2000
We evaluated a vaccinia-vectored vaccine for hemorrhagic fever with renal syndrome in clinical trials. A Phase I dose-escalation study in 16 volunteers divided into four groups demonstrated that subcutaneous inoculation of approximately 10(7) plaque-forming units of the recombinant virus was safe and immunogenic.
McCain, David, Summers, Peter, Harrison, Stephen, Schmaljohn, Alan, Schmaljohn, Connie   +4 more
openaire   +3 more sources

Prevalence and associated factors of human haemorrhagic fevers in Senegal: a comprehensive analysis of Hantaan, Crimean-Congo haemorrhagic fever and Rift Valley fever

Frontiers in Public Health
IntroductionViral haemorrhagic fevers such as Rift Valley fever, Crimean-Congo haemorrhagic fever, and hantavirus disease continue to threaten public health in Africa.
Maryam Diarra, Safietou Sankhe, Mamadou Aliou Barry, Fatoumata Diene Sarr, Mamadou Korka Kindy Diallo, Joseph Faye, Mame Astou Gassama, Maimouna Mbanne, Ousmane Faye, Cheikh Talla, Robab Katani, Keersten Ricks, Moussa Moise Diagne, Jessica Radzio-Basu, Cheikh Loucoubar   +14 more
doaj   +1 more source

Hantaan virus nucleocapsid protein stimulates MDM2-dependent p53 degradation

Journal of General Virology, 2013
Apoptosis has been shown to be induced and downregulated by the Hantaan virus (HTNV) nucleocapsid (N) protein. To address these conflicting data, expression of the p53 protein, one of the key molecules involved in apoptosis, was assessed in the presence of the N protein in A549 and HeLa cells. The amount of p53, increased by drug treatment, was reduced
Sun-Whan, Park, Myung-Guk, Han, Chan, Park, Young Ran, Ju, Byung-Yoon, Ahn, Jungsang, Ryou   +5 more
openaire   +2 more sources

Human recombinant neutralizing antibodies against hantaan virus G2 protein

Virology, 2003
Old world hantaviruses, causing hemorrhagic fever with renal syndrome (HFRS), still present a public health problem in Asia and Eastern Europe. The majority of cases has been recorded in China. The aim of our study was to generate human recombinant neutralizing antibodies to a hantavirus by phage display technology.
Koch, Joachim, Liang, Mifang, Queitsch, Iris, Kraus, Annette A, Bautz, Ekkehard K.F   +4 more
openaire   +2 more sources

The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China

Human Vaccines & Immunotherapeutics, 2017
Xianyang city is one of the main hemorrhagic fever with renal syndrome (HFRS) epidemic areas in northwest China. Although the HFRS immunity program has been provided in this city, HFRS is still occurred every year.
Zhuo Li, Hanyu Zeng, Ying Wang, Yusi Zhang, Linfeng Cheng, Fanglin Zhang, Yingfeng Lei, Boquan Jin, Ying Ma, Lihua Chen   +9 more
doaj   +1 more source