Results 301 to 310 of about 290,368 (328)
Some of the next articles are maybe not open access.
2012
The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference.
Olivier, Delaneau +1 more
openaire +2 more sources
The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference.
Olivier, Delaneau +1 more
openaire +2 more sources
The MHC haplotypes of the chicken
Immunogenetics, 1982The major histocompatibility complex (MHC) of Gallus gallus is the B complex of which three classes of cell-membrane antigens have been clearly defined by serological, histogenetic, and biochemical methods. Two of these classes are homologous to classes I and II of mammals (B-F and B-L, respectively), while the third (B-G) is a differentiation antigen ...
Morten Simonsen +3 more
openaire +3 more sources
2017
Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Sunah, Song, Xin, Li, Jing, Li
openaire +2 more sources
Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Sunah, Song, Xin, Li, Jing, Li
openaire +2 more sources
Haplotyping by capillary electrophoresis
Journal of Chromatography A, 2005The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of genetic markers and polymorphisms throughout the whole genome, more and more attention is focused on the ...
Eszter Szantai +4 more
openaire +3 more sources
Haplotype Inference and Haplotype Information
2004Haplotypes have become increasingly popular because of the abundance of single nucleotide polymorphisms (SNPs) and the limited power of the single-locus analyses. To contend with some weaknesses of the existing haplotype inference methods, we propose new algorithms based on the partition-ligation idea.
openaire +2 more sources
Empirical Exploration of Perfect Phylogeny Haplotyping and Haplotypers
2003The next high-priority phase of human genomics will involve the development of a full Haplotype Map of the human genome [15]. It will be used in large-scale screens of populations to associate specific haplotypes with specific complex genetic-influenced diseases.
Ren-Hua Chung, Dan Gusfield
openaire +2 more sources
Biometrics, 1988
Previous work on the inheritance of disease has often used certain measures of HLA haplotype concordance (such as the number of haplotypes "identical by descent," IBD) among affected siblings from each of a number of sibships, each of which contains at least two affected siblings. Here we introduce a new measure of HLA haplotype discordance between the
Mamdouh Montasser, J. R. Green
openaire +3 more sources
Previous work on the inheritance of disease has often used certain measures of HLA haplotype concordance (such as the number of haplotypes "identical by descent," IBD) among affected siblings from each of a number of sibships, each of which contains at least two affected siblings. Here we introduce a new measure of HLA haplotype discordance between the
Mamdouh Montasser, J. R. Green
openaire +3 more sources
Haplotyping as Perfect Phylogeny
2004We consider the following problem: Given n genotypes, does there exist a set H of haplotypes such that each genotype is generated by a pair from this set, and this det can be derived on a perfect phylogeny. Recently, Gusfield, 2002, presented a polynomial time algorithm to solve this problem that uses established results from matroid and graph theory ...
Bafna V. +3 more
openaire +2 more sources
Mixed haplotypes and autoimmunity
Immunology Today, 1993Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the ...
Benjamin D. Schwartz +3 more
openaire +3 more sources
Algorithms for inferring haplotypes
Genetic Epidemiology, 2004AbstractHaplotype phase information in diploid organisms provides valuable information on human evolutionary history and may lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. Molecular haplotyping methods are labor‐intensive, low‐throughput, and very costly.
openaire +3 more sources