Results 311 to 320 of about 290,368 (328)
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Haplotype‐Association Analysis
2008Association methods based on linkage disequilibrium (LD) offer a promising approach for detecting genetic variations that are responsible for complex human diseases. Although methods based on individual single nucleotide polymorphisms (SNPs) may lead to significant findings, methods based on haplotypes comprising multiple SNPs on the same inherited ...
Hongyu Zhao, Nianjun Liu, Kui Zhang
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Endocrine Research, 1995
Polymorphisms affecting the synthesis of aldosterone or its regulation may have effects on blood pressure. For example, an autosomal dominant form of human hypertension, glucocorticoid suppressible hyperaldosteronism, is caused by recombination between the genes for aldosterone synthase (CYP11B2) and steroid 11 beta-hydroxylase (CYP11B1), creating a ...
Perrin C. White, Liliya Slutsker
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Polymorphisms affecting the synthesis of aldosterone or its regulation may have effects on blood pressure. For example, an autosomal dominant form of human hypertension, glucocorticoid suppressible hyperaldosteronism, is caused by recombination between the genes for aldosterone synthase (CYP11B2) and steroid 11 beta-hydroxylase (CYP11B1), creating a ...
Perrin C. White, Liliya Slutsker
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Estimation of haplotype frequencies
Tissue Antigens, 1983Maximum likelihood estimates of haplotype frequencies in multilocus systems are often zero and so may be genetically inacceptable. Estimation problems are discussed, and preferable estimates are derived.
Lew R +3 more
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Nature Biotechnology, 2016
Short-read sequencing provides haplotype information when long DNA fragments are barcoded in microfluidic droplets.
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Short-read sequencing provides haplotype information when long DNA fragments are barcoded in microfluidic droplets.
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Multifactor Dimensionality Reduction for Detecting Haplotype-Haplotype Interaction
2009 Sixth International Conference on Fuzzy Systems and Knowledge Discovery, 2009The multifactor dimensionality reduction (MDR) is a model-free approach that can identify SNP × SNP effects in a case-control study. In this study, we extended MDR to identify interactions among haplotypes (Hap-MDR). With Hap-MDR, multilocus haplotype genotypes were pooled into high-risk and low-risk groups, effectively reducing the haplotype genotypes
Zhiqiang Chen +7 more
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Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
Neurogenetics, 2004We and others have previously detected association of the Tau H1 haplotype on chromosome 17 with risk of idiopathic Parkinson disease (PD). The H1 haplotype appears to have a fundamental importance in neurodegeneration, as multiple studies have shown it is also associated with an increased risk for progressive supranuclear palsy, corticobasal ...
Burton L. Scott +9 more
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Approaches To Estimation Of Haplotype Frequencies And Haplotype-Trait Associations
2009Characterizing the genetic contributors to complex disease traits will inevitably require consideration of haplotypic phase, the specific alignment of alleles on a single homologous chromosome. In population based studies, however, phase is generally unobservable as standard genotyping techniques provide investigators only with data on unphased ...
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2011
You are shown the results of red cell phenotyping of a 40-year-old woman, 29 weeks into twin pregnancy, and the results of both fetuses (in the brackets are shown probable Rh genotypes, Wiener nomenclature):
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You are shown the results of red cell phenotyping of a 40-year-old woman, 29 weeks into twin pregnancy, and the results of both fetuses (in the brackets are shown probable Rh genotypes, Wiener nomenclature):
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