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Haplotype Inference Constrained by Plausible Haplotype Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2009The haplotype inference problem (HIP) asks to find a set of haplotypes which resolve a given set of genotypes. This problem is important in practical fields such as the investigation of diseases or other types of genetic mutations. In order to find the haplotypes which are as close as possible to the real set of haplotypes that comprise the genotypes ...
Frances A. Rosamond +5 more
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Ancestral haplotypes: conserved population MHC haplotypes
Human Immunology, 1992We describe here a number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc. These haplotypes and recombinants between any two of them account for 73% of unselected haplotypes in our Caucasoid population. The existence of ancestral haplotypes implies conservation of large chromosomal segments. Irrespective of
Campbell S. Witt +5 more
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An Algorithm for Haplotype Analysis
Journal of Computational Biology, 1997This paper proposes an algorithm for haplotype analysis based on a Monte Carlo method. Haplotype configurations are generated according to the distribution of joint haplotypes of individuals in a pedigree given their phenotype data, via a Markov chain Monte Carlo algorithm.
Terence P. Speed, Shili Lin
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2011
Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Xin, Li, Jing, Li
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Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Xin, Li, Jing, Li
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The MHC haplotypes of the chicken
Immunogenetics, 1982The major histocompatibility complex (MHC) of Gallus gallus is the B complex of which three classes of cell-membrane antigens have been clearly defined by serological, histogenetic, and biochemical methods. Two of these classes are homologous to classes I and II of mammals (B-F and B-L, respectively), while the third (B-G) is a differentiation antigen ...
Morten Simonsen +3 more
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2012
The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference.
Olivier, Delaneau +1 more
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The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference.
Olivier, Delaneau +1 more
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Science, 2006
Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous position, code for differences in COMT ...
K. Shokat +13 more
semanticscholar +1 more source
Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous position, code for differences in COMT ...
K. Shokat +13 more
semanticscholar +1 more source
2017
Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Sunah, Song, Xin, Li, Jing, Li
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Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms.
Sunah, Song, Xin, Li, Jing, Li
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Haplotyping by capillary electrophoresis
Journal of Chromatography A, 2005The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of genetic markers and polymorphisms throughout the whole genome, more and more attention is focused on the ...
Eszter Szantai +4 more
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Haplotype Inference and Haplotype Information
2004Haplotypes have become increasingly popular because of the abundance of single nucleotide polymorphisms (SNPs) and the limited power of the single-locus analyses. To contend with some weaknesses of the existing haplotype inference methods, we propose new algorithms based on the partition-ligation idea.
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