Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. [PDF]
This review focuses on the biologic importance of the vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions.
Abbas+130 more
core +2 more sources
Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan+4 more
wiley +1 more source
Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans
The transition from a non‐atherosclerotic to an atherosclerotic artery is associated with a shift in macrophage phenotypes. In the homeostatic environment of a non‐atherosclerotic artery, macrophages are predominantly anti‐inflammatory, anti‐atherogenic.
Barbora Muffova+11 more
wiley +1 more source
Investigations into the fibrinolytic system and haptoglobin types in certain hereditary and acquired haemostatic disorders and the presence of circulating anticoagulants in such states [PDF]
I THE FIBRINOLYTIC SYSTEM: A review of the literature is presented together with an evaluation of the present methods for the measurement of its parameters.The methods adopted in the course of this study include (l) the heated fibrin plate for the ...
Kamel, Karim
core
ABSTRACT Objective To assess foetal circulating free foetal haemoglobin (fHbF) levels and heme defences, correlated to foetal circulatory biometry and foetal sex in severe early‐onset foetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset foetal growth restriction pregnancies with close clinical ...
Adam Brook+17 more
wiley +1 more source
Early‐onset muscle weakness syndrome (MW) in an Australian Holstein calf
Early‐onset muscle weakness syndrome (MW) is a recessive genetic disorder known to affect Holstein cattle. This report describes the clinical findings in an Australian Holstein calf diagnosed with MW. The calf initially presented for examination at a dairy farm at 3 days of age, being recumbent since birth but able to stand with assistance.
MG Ciacia, AJ Phipps
wiley +1 more source
Iron overload in hereditary spherocytosis: Are genetic factors the cause?
Summary Non‐transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next‐generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association ...
Lucie Donaty+6 more
wiley +1 more source
Summary We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic
Urshita Sinha+8 more
wiley +1 more source
Elevated serum level and altered glycosylation of _1-acid glycoprotein in hyperimmunoglobulinemia D and periodic fever syndrome: evidence for persistent inflammation [PDF]
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Dijk, W. van+4 more
core
Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi+19 more
wiley +1 more source