Results 61 to 70 of about 7,568 (236)
Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial
American Journal of Hematology, Volume 101, Issue 2, Page 242-254, February 2026.ABSTRACT
Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari +13 morewiley +1 more sourceCost-effectiveness of non-invasive methods for assessment and monitoring of liver fibrosis and cirrhosis in patients with chronic liver disease: systematic review and economic evaluation [PDF]
, 2015 BACKGROUND: Liver biopsy is the reference standard for diagnosing the extent of fibrosis in chronic liver disease; however, it is invasive, with the potential for serious complications., , , , , , , , , , , , , , , , , , , , , , , Adams, Adams, Afdhal, Aguirre, Ahmad, Aithal, Al-Mohri, Anaparthy, Andersson, Angulo, Arena, Argo, Asbach, Ascher, Aube, Aube, Awaya, Barshop, Barton, Bataller, Beckebaum, Bedossa, Bejarano, Belfort, Bellentani, Ben Jazia, Bennett, Berg, Blomme, Bolondi, Bonkovsky, Boring, Borroni, Bourliere, Boursier, Boursier, Briggs, Brown, Brunetto, Buntinx, Burton, Cales, Cales, Cales, Calvaruso, Calvaruso, Calvaruso, Camma, Cardi, Cardoso, Carlson, Carrion, Carvalho-Filho, Castera, Castera, Castera, Castera, Castera, Castera, Ceriani, Chalasani, Chalasani, Chan, Chang, Chavez-Tapia, Cheinquer, Chen, Chen, Chen, Cheung, Cho, Cholongitas, Chong, Chou, Christensen, Chrysanthos, Cioni, Claxton, Cobbold, Colletta, Colli, Colli, Colombo, Corradi, Crespo, Cross, Crowley, Crowley, Curtis, da Silva, Dakin, Danila, David, Davis, de Franchis, De Freitas, De Jongh, de Ledinghen, De Ledinghen, Degos, Denzer, Detre, Di Bisceglie, Di Marco, Dinesen, Dixon, Dixon, Do, Donnan, Drummond, Dusheiko, D’Amico, D’Onofrio, Ekstedt, Esmat, Esteban, Fabris, Fahmy, Fattovich, Fattovich, Fattovich, Fattovich, Fattovich, Fattovich, Feldstein, Fenwick, Ferral, Fontaine, Fontana, Fontanges, Forestier, Forns, Fraquelli, Fried, Fried, Friedrich-Rust, Fujii, Fujimoto, Fung, Gaia, Gaia, Gaiani, Ganne-Carrie, Gara, Germani, Germani, Giannini, Gierblinski, Gobel, Goodman, Goyal, Grieve, Grishchenko, Guajardo-Salinas, Guechot, Guechot, Guha, Gui, Guo-Qiu, Guzelbulut, Hadziyannis, Halfon, Halfon, Halfon, Hall, Harada, Harrison, Haukeland, Hongbo, Hoofnagle, Hsieh, Hu, Huang, Hui, Huwart, Iacobellis, Ibrahim, Idilman, Imbert-Bismut, Imperiale, Isgro, Ishibashi, Islam, Iushchuk, Jacobson, Jacobson, Jacobson, Janssens, John-Baptiste, Jones, Jones, Joseph, Kalantari, Kamal, Kamphues, Kandemir, Kaneda, Kayadibi, Kelleher, Kelleher, Khan, Khosravi, Kilpe, Kim, Kim, Kim, Kim, Kim, Kim, Kim, Kim, Koda, Koizumi, Kwok, Lackner, Ladenheim, Ladero, Lai, Lampertico, Lau, Lavallard, Lavanchy, Lavine, Lawitz, Lee, Lee, Lee, Leroy, Leroy, Leroy, Lesmana, Levy, Lewin, Li, Liaw, Liaw, Lichtinghagen, Lieber, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Loko, Longworth, Lupsor, Lupsor, Lupsor, Lutz, Lydatakis, Macaskill, Macias, Macias, Mahadeva, Mahady, Mahady, Mallet, Manns, Manns, Manousou, Manousou, Marcellin, Marcellin, Marcellin, Martinez, Martinez, McLernon, McPherson, McPherson, Melin, Miailhes, Mohamadnejad, Moreno-Otero, Morgan, Morikawa, Motosugi, Mueller, Mummadi, Murawaki, Musso, Myers, Myers, Nagata, Nahon, Naveau, Naveau, Nguyen-Khac, Nishiura, Nitta, Nojiri, Numminen, Nunes, Obara, Ogawa, Oliveira, Ong, Orlacchio, Orlacchio, Osakabe, O’Shea, Paggi, Pais, Palmeri, Papalavrentios, Parise, Park, Park, Park, Park, Park, Parkes, Patel, Patel, Pawitpok, Pereira, Petta, Pimentel, Pohl, Poordad, Poynard, Poynard, Poynard, Poynard, Prati, Promrat, Qian, Qiu, Qureshi, Raftopoulos, Rakoski, Ramachandran, Raszeja-Wyszomirska, Ratziu, Ratziu, Ratziu, Ratziua, Realdi, Reedy, Reitsma, Ronot, Rosenberg, Rossi, Rossini, Ruffillo, Rustogi, Saab, Said, Saitou, Sakugawa, Sancheztapias, Sandrasegaran, Santos, Sanvisens, Sanyal, Sanyal, Sanyal, Schiavon, Schiavon, Schneider, Schneider, Schuetz, Sebastian, Sebastiani, Sebastiani, Sebastiani, Sebastiani, Sene, Seto, Sharabash, Shastry, Shen, Shepherd, Shepherd, Shepherd, Sherman, Sheth, Shields, Shiffman, Shimada, Shin, Shinkins, Shiramizu, Siebert, Sinakos, Singal, Sirli, Snyder, Snyder, Sohn, Sohn, Sokucu, Sonnenberg, Sporea, Sporea, Sporea, Sporea, Sporea, Standish, Sterling, Stevenson, Stibbe, Sud, Sumida, Sumida, Suzuki, Sweeting, Takeda, Tassopoulos, Terjung, Testa, Thompson, Thompson, Thompson, Thompson Coon, Thompson Coon, Tillmann, Tome, Toniutto, Tran, Trang, Trifan, Trocme, Tsochatzis, Tsochatzis, Tsochatzis, Tsochatzis, Tsochatzis, Tural, Uygun, Vallet-Pichard, Valva, Vanbiervliet, Varaut, Veenstra, Veenstra, Venkatesh, Vernon, Verrill, Viana, Vigano, Viganò, Wai, Wang, Wang, Ware, Westin, Whiting, Whiting, Whiting, Whiting, Wilby, Wilck, Wilson, Wong, Wong, Wong, Wong, Wong, Wong, Wong, Wong, Woo, Wright, Wu, Xu, Yoneda, Yoneda, Younossi, Younossi, Yuen, Zaman, Zarski, Zarski, Zhang, Zhang, Zhang, Zhu, Zhu, Ziol +503 morecore +2 more sourcesDigenic Functional B12 and Folate Defect Mimicking Myelodysplasia
Clinical Case Reports, Volume 14, Issue 2, February 2026.Proposed mechanistic model of mutation‐related outcomes. ABSTRACT
A digenic defect involving CUBN and MTHFR produced functional B12/folate deficiency in a patient with pancytopenia and neurological signs, mimicking myelodysplasia. Genetic and metabolic screening revealed elevated methylmalonic acid/homocysteine, with rapid remission post‐parenteral B12.Thomas Cluzeau, Abderrahim Oussalah, Maël Silva Rodriguez, Mourad Naïmi +3 morewiley +1 more sourceProteomic and metabonomic biomarkers for hepatocellular carcinoma: a comprehensive review [PDF]
, 2014 Hepatocellular carcinoma (HCC) ranks third in overall global cancer-related mortality. Symptomatic presentation often means advanced disease where potentially curative treatment options become very limited.Fye, H, Holmes, E, Kimhofer, T, Taylor-Robinson, S, Thursz, M +4 morecore +2 more sourcesFree Fetal Haemoglobin in Severe Early‐Onset Fetal Growth Restriction: A Prospective Multi‐Centre Study
BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 401-411, February 2026.ABSTRACT Objective
To assess fetal circulating free fetal haemoglobin (fHbF) levels and heme defences, correlated to fetal circulatory biometry and fetal sex in severe early‐onset fetal growth restriction (FGR). Design, Setting and Population
A prospective study severe early‐onset fetal growth restriction pregnancies with close clinical management ...Adam Brook, Georgia Baynes, Jonathan Scargill, Angelos Evangelinos, Charlotte Brennan‐Richardson, Freya Dow, Yuval Ginsberg, Tal Weissbach, Jana Brodszki, Eva Hansson, Anke Diemert, Kurt Hecher, Katarzyna Maksym, Neil Marlow, Rebecca N. Spencer, Anna L. David, Stefan R. Hansson, Paul Brownbill +17 morewiley +1 more sourceUnveiling the Dual Expression of Haptoglobin in Malignant Hepatocellular Carcinoma Cells through Single-Cell and Bulk RNA Sequencing Analysis [PDF]
, 2023 Fukuan Du, Lin Liu, Siyu Hao, Shuang Gou, Xiaolong Tang, Yao Zhang, Dan Cai, Mintao Xiao, Xinyi Zhang, Duoli Zhang, Jing Shen, Yan Li, Yu Chen, Yueshui Zhao, Shuai Deng, Xu Wu, Mingxing Li, Zhuo Zhang, Zhangang Xiao +18 moreopenalex +1 more sourceFamilial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis
Journal of Clinical Periodontology, Volume 53, Issue 2, Page 222-231, February 2026.ABSTRACT Aim
To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods
Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC).Hélvis E. S. Paz, Mabelle F. Monteiro, Camila S. Stolf, Cássia F. Araújo, Angelika Silbereisen, Mauro P. Santamaria, Nagihan Bostanci, Renato C. V. Casarin +7 morewiley +1 more sourceReceptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz +5 morewiley +1 more source
