Results 101 to 110 of about 2,382,016 (345)
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Some Results on Factorization of Monoids [PDF]
arXiv, 2022 Factorizations of monoids are studied. Two necessary and sufficient conditions in terms of so-called descent 1-cocyles for a monoid to be factorized through two submonoids are found. A full classification of those factorizations of a monoid whose one factor is a subgroup of the monoid is obtained.
arxiv
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Surface plasmon and photonic mode propagation in gold nanotubes with varying wall thickness [PDF]
, 2011 Gold nanotube arrays are synthesized with a range of wall thicknesses (15 to >140 nm) and inner diameters of ∼200 nm using a hard-template method.
Fireman, Micha +2 more
core +1 more source
Interpretable Sparse Proximate Factors for Large Dimensions [PDF]
arXiv, 2018 This paper proposes sparse and easy-to-interpret proximate factors to approximate statistical latent factors. Latent factors in a large-dimensional factor model can be estimated by principal component analysis (PCA), but are usually hard to interpret.
arxiv
Factor Investing with a Deep Multi-Factor Model [PDF]
arXiv, 2022 Modeling and characterizing multiple factors is perhaps the most important step in achieving excess returns over market benchmarks. Both academia and industry are striving to find new factors that have good explanatory power for future stock returns and good stability of their predictive power.
arxiv
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
k-Center Clustering Under Perturbation Resilience [PDF]
, 2016 The k-center problem is a canonical and long-studied facility location and clustering problem with many applications in both its symmetric and asymmetric forms.
Balcan, Maria-Florina +2 more
core +1 more source
American Journal of Preventive Cardiology, 2022 More than half of U.S. young adults have low ten-year but high lifetime risk of cardiovascular disease (CVD). Improving primary prevention in young adulthood may help reduce persistent CVD disparities and overall CVD morbidity and mortality. The National
Ann Marie Navar +17 more
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