Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
Ultrasound Archiving in the Emergency Department: Implementation, Governance and 4-Year Outcomes at an Australian Tertiary Emergency Department. [PDF]
Manivel V +3 more
europepmc +1 more source
A Sr‐free air electrode for high‐temperature solid oxide cells is designed by independently tailoring electronic conduction, ionic transport, and surface catalysis using complementary Sr‐free phases and infiltrated nanocatalysts. It delivers performance comparable to state‐of‐the‐art Sr‐containing electrodes while completely suppressing Cr‐induced ...
Ji‐eun Won +10 more
wiley +1 more source
Silicon-On-Sapphire Metasurfaces Generate Arrays of Dark and Bright Traps for Neutral Atoms. [PDF]
Fang C +12 more
europepmc +1 more source
Bio‐Inspired Gradient Coatings Enhance the Leading Edge Erosion Resistance of Wind Blades
Rain‐induced erosion of the wind turbine blade leading edge poses a critical challenge to maintenance and operation. Here, we propose a bio‐inspired approach for erosion protection utilising a platelet‐reinforced polyurethane coating with a graded through‐thickness architecture.
Natalia Sofia Guevara‐Sotelo +2 more
wiley +1 more source
Three-dimensional niche-like porous structure locoregionally regulating macrophage immunosenescence rejuvenates aged bone repair. [PDF]
Zhao DW +10 more
europepmc +1 more source
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
Development of a high-performance in-memory database architecture for intelligent video surveillance in critical patient care. [PDF]
Veerapaneni RK +3 more
europepmc +1 more source
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
Superferromagnetic Disk Particles for Magnetic Particle Imaging. [PDF]
Mayr EM +7 more
europepmc +1 more source

