Results 41 to 50 of about 346,551 (253)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nature-inspired optimization algorithms in knapsack problem: A review [PDF]
المجلة العراقية للعلوم الاحصائية, 2019 Meta-heuristic algorithms have become an arising field of research in recent years. Some of these algorithms have proved to be efficient in solving combinatorial optimization problems, particularly knapsack problem.
Ghalya Tawfeeq Basheer, Zakariya Algamal
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Complexity and Distribution of Hard Problems
SIAM Journal on Computing, 1995 Summary: Measure-theoretic aspects of the \(\leq^{\text{P}}_m\)-reducibility structure of the exponential time complexity classes \(\text{E} = \text{DTIME}(2^{\text{linear}})\) and \(\text{E}_2 = \text{DTIME}(2^{\text{polynomial}})\) are investigated.
David W. Juedes, Jack H. Lutz
openaire +4 more sources
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Mind/body “hard problem” is not a category error
Animal Sentience, 2016 Reber’s Cellular Basis of Consciousness (CBC) has much to recommend it. However, while the CBC effectively renders null any ontological gap between mind and body, it leaves two important remaining gaps unaddressed: the epistemologic and the causal gap ...
Linda A.W. Brakel
doaj +1 more source
Safe Approximation—An Efficient Solution for a Hard Routing Problem
Algorithms, 2021 The Disjoint Connecting Paths problem and its capacitated generalization, called Unsplittable Flow problem, play an important role in practical applications such as communication network design and routing. These tasks are NP-hard in general, but various
András Faragó, Zohre R. Mojaveri
doaj +1 more source
Reoptimization of NP-Hard Problems [PDF]
, 2018 A reoptimization problem, given two similar instances of an optimization problem and a good solution to the first instance, asks for a solution to the second. In this paper we propose general approximation algorithms applicable to a wide class of reoptimization problems.
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Mathematics, 2023 Because of hyper-complexity, a difficulty to define, multiple stakeholders with conflicting perspectives, and a lack of clear-cut solutions, wicked problems necessitate innovative and adaptive strategies. Operations research (OR) has been a valuable tool
Wenjing Xu +2 more
doaj +1 more source