Results 121 to 130 of about 2,949,351 (299)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Soft skills and hard skills, key to comprehensive professional training
, 2022 La sociedad experimenta cambios constantes que requieren de profesionales con capacidades de adaptación y toma decisiones para la resolución de problemas que se puedan presentar en su entorno, en ese sentido, el propósito del presente artículo es determinar cómo las habilidades blandas y habilidades duras son claves para la formación de profesionales ...
Ramírez Chávez., Máximo Abel +1 more
openaire +1 more source
Innovation, skills and performance in the downturn: an analysis of the UK innovation survey 2011 [PDF]
, 2014 The link between firms’ innovation performance and economic cycles, especially major downturns such as that of 2008-10, is a matter of great policy significance, but is relatively under-researched at least at the level of micro data on business ...
Frenz, Marion, Lambert, Ray
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
University image, hard skills or soft skills
We explore the relationships between student satisfaction and its antecedents-perceived value, university image, and perceived quality-from the perspective of employed graduate students from a Spanish technical university. To determine how students were segmented in our structural model, a general model was tested using partial least squares structural
Lamberti, Giuseppe|| +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
League-ally Speaking was a newsletter published by the Toledo League for the Hard of Hearing in Toledo, Ohio. Incorporated in 1920, the organization was also an agency of the Toledo Community Chest. In 1947 the organization changed its name to the Toledo
Toledo League for the Hard of Hearing
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Інформаційні технології і засоби навчання, 2017 The problem of technological universities lagging behind the level of development of the IT-industry can be solved only on condition that technological IT companies actively participate in training of future IT-professionals.
Olena G. Glazunova +2 more
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