Results 181 to 190 of about 908,576 (290)

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Functional annotation and analysis of the hard tick Dermacentor nuttalli midgut genes. [PDF]

Parasitol Res
Ma H, Jia L, Feng J, Li T, Li C, Li J, Xuan X, Sun Y.   +7 more
europepmc   +1 more source

Proteomic fingerprinting of Neotropical hard tick species (Acari: Ixodidae) using a self-curated mass spectra reference library. [PDF]

PLoS Negl Trop Dis, 2020
Gittens RA, Almanza A, Bennett KL, Mejía LC, Sanchez-Galan JE, Merchan F, Kern J, Miller MJ, Esser HJ, Hwang R, Dong M, De León LF, Álvarez E, Loaiza JR.   +13 more
europepmc   +1 more source

Tick-borne encephalitis (TBE) [PDF]

Tick-borne encephalitis, or TBE, is a human viral infectious disease involving the central nervous system. TBE is caused by the tick- borne encephalitis virus (TBEV), a member of the family Flaviviridae, and was initially isolated in 1937.

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Antigenic variation is caused by long plasmid segment conversion in a hard tick-borne relapsing fever Borrelia miyamotoi. [PDF]

PLoS Pathog
Takeuchi T, Gotoh Y, Hayashi T, Kawabata H, Takano A.   +4 more
europepmc   +1 more source

A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing

Angewandte Chemie International Edition, EarlyView.
Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs, Albert Kraft, Vahideh Mahram, Marco Neumaier, Papri Chakraborty, Emily Janz, Maria Vittoria Balli, Pierre Picchetti, Luca Prodi, Manfred Kappes, Frank Biedermann   +10 more
wiley   +1 more source

In Silico Analysis of Two Hard Tick P450s: Identification, Characterization, and Putative Metabolism of <i>Cymbopogon citratus</i> Essential Oil Constituents. [PDF]

Int J Mol Sci
Li C, Wen L, Shi W, Deng Y, Zhou N, Zhao X, Guo Q, Gailike B.   +7 more
europepmc   +1 more source

League-ally Speaking, 1943

League-ally Speaking was a newsletter published by the Toledo League for the Hard of Hearing in Toledo, Ohio. Incorporated in 1920, the organization was also an agency of the Toledo Community Chest. In 1947 the organization changed its name to the Toledo
Toledo League for the Hard of Hearing
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Corrigendum to “Hard ticks and tick-borne pathogens in Mongolia—A review” [Ticks Tick-Borne Dis. 10 (2019) 101268]

Ticks and Tick-borne Diseases, 2021
Jiří Černý, Buyantogtokh Buyannemekh, Tersia Needham, Gantulga Gankhuyag, Dashzeveg Oyuntsetseg   +4 more
openaire   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source