Results 281 to 290 of about 1,187,841 (327)

pH‐Controlled Gliding Motions in Pillar[5]arene‐Containing Molecular Shuttles

ChemistryEurope, EarlyView.
The perfectly reversible protonation/deprotonation of pillar[5]arene‐based molecular shuttles allows to control the amplitude of the gliding motions of the macrocyclic component along the axle moiety. Such motions occur over the full length of the molecular axle in the protonated state.
Nihed Becharguia, Iwona Nierengarten, Alix Sournia‐Saquet, Emeric Wasielewski, Rym Abidi, Béatrice Delavaux‐Nicot, Jean‐François Nierengarten   +6 more
wiley   +1 more source

Amine‐AlH3 Adducts as Energetic Materials for a New Generation of Solid Fuels

Chemistry – A European Journal, EarlyView.
New amine‐AlH₃ adducts offer a more environmentally friendly, high‐energy alternative to conventional rocket propellants, and exhibit ultra‐fast ignition. They can be synthesized by mechanochemical method under hydrogen pressure starting from aluminum metal directly or by wet chemical processes with AlH3.
Xiaoran Liu, Jochen Ortmeyer, Alexander Bodach, Hilke Petersen, Michael Felderhoff   +4 more
wiley   +1 more source

Controlling Topology of a Telomeric G‐quadruplex DNA With a Chemical Cross‐link

Chemistry – A European Journal, EarlyView.
Thermodynamically stable G‐quadruplex (G4) DNA: Chemical cross‐linking between distant nucleotides led to formation of G4‐DNA that is stable in the presence of complementary DNA. This methodology can be used to reliably form G4s within DNA fibers for subsequent structural studies of G4‐protein interactions.
Bruce Chilton, Patrick J. B. Edwards, Geoffrey B. Jameson, Tracy K. Hale, Vyacheslav V. Filichev   +4 more
wiley   +1 more source

Bioorthogonal Click‐to‐Release of Branched Pro‐Fluorophores

Chemistry – A European Journal, EarlyView.
Alkene‐azide click‐to‐release branched prodrugs can amplify the amount of cargo activated. However, balance between the “click” and “release” steps is essential. Branched pro‐fluorophores provided the fastest‐to‐date click reaction of aryl azides and TCOs. The second branched core enabled the self‐immolation, releasing higher levels of fluorophore than
Thomasin Brind, Aggie Lawer, Tobias Todd, Sushant Aryal, Sarah Hook, Allan B. Gamble   +5 more
wiley   +1 more source

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

Chemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker, Jan‐Simon Behnke, Leonhard H. Urner   +2 more
wiley   +1 more source

Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin

Cytoskeleton, EarlyView.
ABSTRACT Actin filaments are dynamic polymers whose length depends on regulated monomer association and dissociation at their ends. Actin barbed‐end dynamics are relatively better understood, primarily due to the approximately tenfold faster subunit on/off rates at barbed versus pointed ends.
Sawako Yamashiro, Shashank Shekhar, Stefanie M. Novak, Sudipta Biswas, Carol C. Gregorio, Velia M. Fowler   +5 more
wiley   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Cytoskeleton, EarlyView.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley, Taylor Mahoney, Christian Pagán Medina, Parsa Zareiesfandabadi, Matthew B. Rapp, Mastawal Tirfe, Sharonda J. LeBlanc, Meredith D. Betterton, Mary Williard Elting   +8 more
wiley   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

ChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann   +4 more
wiley   +1 more source

Broad‐Spectrum Diffusion Coefficient Measurements via Surface Plasmon Resonance: From Thermodynamics to Protein Conformational Disorders

ChemPhysChem, EarlyView.
Recent advancements in surface plasmon resonance protocols and simulations have enhanced the measurement and prediction of diffusion coefficients (D) for chemical species in microfluidic channels. These developments enable precise determination of D values for molecules ranging from a few angstroms to nanometric aggregates, facilitating detailed ...
Giuseppe Stefano Basile, Damiano Calcagno, Nunzio Tuccitto, Diego Sbardella, Giuseppe Grasso   +4 more
wiley   +1 more source

Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2Y12 Inhibitor Prescribing

Clinical Pharmacology &Therapeutics, EarlyView.
P2Y12 inhibitor selection involves numerous factors, including CYP2C19 genetics, since evidence demonstrates reduced clopidogrel efficacy in patients with decreased or no function CYP2C19 variants. In 2020, Indiana University health embedded interruptive clinical decision support (CDS) alerts in the electronic health record (EHR) to recommend ...
Ashley N. Springer, Leah A. Alicea, Yemi Gafari, Tayler B. Smith, Sheryl Lynch, Amy M. Breman, Jennelle C. Hodge, Victoria M. Pratt, Nicholas R. Powell, Rolf P. Kreutz, Daniel P. Kobold, Michael T. Eadon, Emma M. Tillman, Tyler Shugg, Todd C. Skaar   +14 more
wiley   +1 more source