Results 131 to 140 of about 45,197 (322)

Simplified cyclic structural analyses of SSME turbine blades [PDF]

open access: yes
Anisotropic high-temperature alloys are used to meet the safety and durability requirements of turbine blades for high-pressure turbopumps in reusable space propulsion systems.
Kaufman, A., Manderscheid, J. M.
core   +1 more source

A Radiation-Hardened, Computer for Satellite Applications

open access: yes, 1996
This paper describes high reliability radiation hardened computers built by Sandia for application aboard Department Of Energy (DOE) Satellite programs requiring 32-bit processing. The computers highlight a radiation hardened (1 Mrad(Si)) R3000 executing up to 10 Million Reduced Instruction Set Instructions (RISC) Per Second (MIPS), a dual purpose ...
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Variance-Aware Noisy Training: Hardening DNNs Against Unstable Analog Computations

open access: yes
The disparity between the computational demands of deep learning and the capabilities of compute hardware is expanding drastically. Although deep learning achieves remarkable performance in countless tasks, its escalating requirements for computational power and energy consumption surpass the sustainable limits of even specialized neural processing ...
Xiao Wang   +3 more
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

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