Results 131 to 140 of about 45,289 (325)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A Radiation-Hardened, Computer for Satellite Applications
, 1996 This paper describes high reliability radiation hardened computers built by Sandia for application aboard Department Of Energy (DOE) Satellite programs requiring 32-bit processing. The computers highlight a radiation hardened (1 Mrad(Si)) R3000 executing up to 10 Million Reduced Instruction Set Instructions (RISC) Per Second (MIPS), a dual purpose ...
openaire +1 more source
Different aspects of low-cycle fatigue [PDF]
The experimental and theoretical knowledge in this field is presented. The different relations which correlate the number of cyles to rupture with strain or strain-energy are given.
Bathias, C.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Beam hardening correction for standard computed tomography using dual-material decomposition.
, 1992 Julia Older
openalex +2 more sources
Simplified cyclic structural analyses of SSME turbine blades [PDF]
Anisotropic high-temperature alloys are used to meet the safety and durability requirements of turbine blades for high-pressure turbopumps in reusable space propulsion systems.
Kaufman, A., Manderscheid, J. M.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Variance-Aware Noisy Training: Hardening DNNs Against Unstable Analog Computations
The disparity between the computational demands of deep learning and the capabilities of compute hardware is expanding drastically. Although deep learning achieves remarkable performance in countless tasks, its escalating requirements for computational power and energy consumption surpass the sustainable limits of even specialized neural processing ...
Xiao Wang +3 more
openaire +2 more sources
Using Approximate Computing and Selective Hardening for the Reduction of Overheads in the Design of Radiation-Induced Fault-Tolerant Systems [PDF]
, 2019 Alexander Aponte-Moreno +2 more
openalex +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source