Results 71 to 80 of about 45,289 (325)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Constitutive modeling for isotropic materials (HOST) [PDF]

The results of the third year of work on a program which is part of the NASA Hot Section Technology program (HOST) are presented. The goals of this program are: (1) the development of unified constitutive models for rate dependent isotropic materials ...
Bodner, S. R., Chan, Kwai S., Hill, Jeff T., Lindholm, Ulric S., Meyer, T. G., Weber, R. M.   +5 more
core   +5 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Fault-tolerant method for anti-SEU of embedded system based on dual-core processor

The Journal of Engineering, 2019
The development of space applications based on commercial system on chip (SOC) FPGA devices has become an important direction for the development of aerospace technology, but single event upsets (SEUs) in space is a difficult problem for commercial SOC ...
Xiuhai Cui, Qi Gao, Ruichao Wang, Li Liu, Jun Liang, Yu Peng   +5 more
doaj   +1 more source

Multi-scale computational model for failure analysis of metal frames that includes softening and local buckling [PDF]

, 2010
In this work we present a new modelling paradigm for computing the complete failure of metal frames by combining the stress-resultant beam model and the shell model.
Brank, Boštjan, Dujc, Jaka, Ibrahimbegović, Adnan   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Dynamic partial reconfiguration scheme for fault-tolerant FFT processor based on FPGA

The Journal of Engineering, 2019
The fast Fourier transform FFT processor is an important part of the space real-time signal processing system based on field programmable gate array (FPGA).
Xin Wei, Yi Z Xie, Yu Xie, He Chen
doaj   +1 more source

Nuclear classical dynamics of H$_2$ in intense laser field

, 2011
In the first part of this paper, the different distinguishable pathways and regions of the single and sequential double ionization are determined and discussed.
Babak Shokri, Brabec T (ed), Dehghanian E, Firoozeh Sami, Giusti-Suzor A, Litvinyuk I V, Liu Z-T, Mohsen Vafaee, Posthumus J H, Rigamonti A, Vafaee M, Vafaee M Sabzyan H Vafaee Z Katanforoush A, Vafaee M Sami F Shokri B   +12 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Enhanced strength and ductility in an additively manufactured Al10SiMg alloy at cryogenic temperatures

Communications Materials
The increasing demand for lightweight materials that maintain mechanical integrity at ultralow temperatures has driven the development of advanced alloys for cryogenic applications.
Muhammad Naeem, Asif Ur Rehman, Liliana Romero Resendiz, Elmas Salamci, Huseyin Aydin, Peyman Ansari, Stefanus Harjo, Wu Gong, Yusuf Usta, Olcay Ersel Canyurt, Xun-Li Wang, Metin U. Salamci   +11 more
doaj   +1 more source