Results 81 to 90 of about 45,197 (322)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Phenomenological modeling of strain hardening, phase transformation and damage effects of trip-steels [PDF]

, 2017
In this study, the constitutive modeling of loading state dependent strain hardening and martensite evolution of high alloyed TRIP-steels are addressed, which are experimentally observed comparing uni-axial tension and compression test results ...
Kuna, Meinhard, Seupel, Andreas
core  

Production of trans-Neptunian binaries through chaos-assisted capture

, 2007
The recent discovery of binary objects in the Kuiper-belt opens an invaluable window into past and present conditions in the trans-Neptunian part of the Solar System. For example, knowledge of how these objects formed can be used to impose constraints on
Canup, D. Farrelly, Deprit, E. A. Lee, Farrelly, Farrelly, Gentleman, Griffiths, Jaffe, Jewitt, S. A. Astakhov, Saini, UZER, Waalkens, Wetherill   +14 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Multi-Objective Response to Co-Resident Attacks in Cloud Environment

International Journal of Information and Communication Technology Research, 2017
Cloud computing is a dynamic environment that offers variety of on-demand services with low cost. However, customers face new security risks due to shared infrastructure in the cloud.
Farzaneh Abazari, Morteza Analoui, Hassan Takabi   +2 more
doaj  

Experimental Research and Computer Simulation of Face Grind-hardening Technology

Strojniški vestnik – Journal of Mechanical Engineering, 2013
By systematic experimental researches on technological parameters such as grinding ways and grinding parameters, influence laws of technological parameters on face grind-hardening surface hardness and hardened layer depth are obtained, which provides reference for choice of reasonable parameters in face grind-hardening processing.
Du, Changlong, Li, Jianping, Liu, Songyong   +2 more
openaire   +2 more sources

Virtual monochromatic imaging reduces beam hardening artefacts in cardiac interior photon counting computed tomography: a phantom study with cadaveric specimens

, 2021
Satu I. Inkinen, Mikael A K Juntunen, Juuso H. Ketola, Kristiina Korhonen, Pasi Sepponen, Antti Kotiaho, Vesa‐Matti Pohjanen, Miika T. Nieminen   +7 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Signed-weight projection for robust in-sensor computing neural classifiers under amplitude-dependent noise and stuck-at faults

Discover Electronics
In-sensor computing (ISC) monolithically integrates photodetection and neural-network inference on the same focal plane, avoiding analog-to-digital conversion and off-chip data movement.
Difei Zhong
doaj   +1 more source