Results 91 to 100 of about 377,802 (293)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

HARDSHIP KLAUZULA

open access: yesGlasnik prava, 2018
Interest in solving the problem of changed circumstances in contractual relationships is shown not only by lawyers, but also by economic entities and their associations. Due to the very narrow application of international and national sources in the court and arbitration practice, the parties, in order to eliminate the uncertainty about whether or not,
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Newspaper of the university of alaska southeast juneau campus [PDF]

open access: yes, 1989
Forrer selected to fill UA Board of regents position -- Grievance process continues for player --NAIA Hardship decision: appeal sought by player -- USUAS votes to fund commencement dance -- Find your future with job skills inventory -- Alaska vs.

core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Navigating Hardship

open access: yesAnnales, Series Historia et Sociologia
This article analyses the practical strategies used by older people living in poverty to navigate their social worlds, which, applying Pierre Bourdieu’s theoretical framework, are framed by ‘positional suffering’ due to low social status.
Nina Perger, Tanja Kamin, Jana Mali
doaj   +1 more source

The Great Recession and Material Hardship [PDF]

open access: yes
Little research looks at the relationship between macroeconomic indicators and material hardship. High unemployment rates as a result of economic downturns are likely to lead to lost income, increased poverty, and material hardship. We examine the effect
Irwin Garfinkel   +2 more
core  

Down and Out: Measuring Long-term Hardship in the Labor Market [PDF]

open access: yes, 2012
The official concept of "long-term unemployment," while useful, is incomplete and, in some cases, even potentially misleading. As tracked by government statistics, the long-term unemployed are only a relatively small part of the population facing ...
Janelle Jones, John Schmitt
core  

Does material disadvantage explain the increased risk of adverse health, educational, and behavioural outcomes among children in lone parent households in Britain? : a cross sectional study [PDF]

open access: yes, 2005
Objective: To test the hypothesis that material disadvantage explains the increased risk among children and young people of adverse health, educational, and behavioural problems associated with living in lone parent households in Britain Study design:
Spencer, Nick
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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