Results 101 to 110 of about 377,802 (293)
L’enquête sociologique et les acteurs faibles
Sociologies, 2011 Sociological investigation of individuals weakened by a social disqualification presents singular issues and requires appropriate skills. These ones are built by experiences of nearness that confronts the researcher to non-familiar moral frameworks ...
Jean-Paul Payet
doaj
Social Sciences and Humanities OpenMaterial hardship is a significant indicator of poverty, offering direct insights into the inability to afford necessities. When examining material hardship, often a decision lies in determining the boundaries that distinguish those who experience ...
Molly Grant, Kane Meissel, Daniel Exeter
doaj +1 more source
, 2004 Happiness is often seen as the fruit of an easy life, but empirical studies show that happiness can go together with considerable hardship. Average happiness is high in current western nations, in spite of chronic problems such as criminality, time ...
Veenhoven, R. (Ruut)
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Behavioral SciencesThe literature provides empirical evidence that family economic hardship can increase the likelihood of adolescents engaging in non-suicidal self-injury (NSSI). However, the mechanisms underlying this relationship remain unclear.
Xiaoyan Liao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
CHEST Critical CareBackground: A high burden of financial hardship has been demonstrated in critically ill patients. Understanding the sociodemographic and clinical risk factors for financial hardship and its association with patient outcomes can help to guide future ...
Alison M. Uyeda, MD +5 more
doaj +1 more source
Exploratory Research into the Resilience of Farming Systems during Periods of Hardship [PDF]
This paper investigates the management strategies and responses used by New Zealand sheep and beef farmers to ensure resilience during periods of hardship.
Parsonson-Ensor, Chris +1 more
core +1 more source
A Fine Balance: Effectively Managing Growth and Contraction [PDF]
, 2010 [Excerpt] Times of economic hardship and prosperity both pose unique challenges to companies and their talent management practices. On one hand, while companies are experiencing contraction, employers may neglect motivating and developing their employees.
Sheranian, Nathan J.
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