Results 111 to 120 of about 377,802 (293)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Children facing economic hardships in the United States [PDF]
This paper helps document significant improvements in the child low-income rate as well as the significant decrease in the proportion of children who relied on public assistance in the United States during the 1990s. Many disadvantaged groups of children
Hsien-Hen Lu +4 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
"The Persistence of Hardship Over the Life Course" [PDF]
This paper focuses on the persistence of hardship from middle age to old age. Proposed status maintenance models suggest that stratification of economic status occurs over the life course (e.g., little mobility is seen within the income distribution ...
Thomas L. Hungerford
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U.S., Midwest Struggling With Stubborn Economic Recovery: 2010 Data Release from the U.S. Census Bureau's Current Population Survey, Annual Social & Economic Supplement [PDF]
, 2011 The newly released poverty data from the U.S. Census Bureau's Current Population Survey provide a glimpse of the ongoing impacts of the Great Recession for millions of individuals and families.
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Steuerung des GKV-Arzneimittelmarktes – Auswirkungen von Selbstbeteiligungen und Härtefallregelungen [PDF]
This analysis shows that hardship and not hardship cases respectively reject clear differences both at the demand and at the expenditures for pharmaceuticals financed by the statutory health insurance.
Anita B. Pfaff +2 more
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Standing on Shaky Ground: Americans' Experiences With Economic Insecurity [PDF]
, 2010 Based on 2009 Surveys of Economic Risk Perceptions and Insecurity, examines Americans' experience of economic insecurity, such as frequency and duration, buffers against hardship, and concerns by income, family structure, race/ethnicity, and ...
Jacob S. Hacker +2 more
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