Results 131 to 140 of about 691,976 (317)

An exploration of triadic family relationships: a systemic-attachment perspective on the experiences of adolescents who self-harm and their parents

, 2013
Self-harm as an expression of emotional pain and hurt is starting to become the consensus view amongst professionals. This present study explored how young people who self-harm and their parents experience the young person’s self-harm and how it affects ...
Karamat Ali, Ramón
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Our stories, our selves: Fictional representations of self-harm

, 2022
Self-harm is often understood, experienced, or culturally positioned as an object which is particularly difficult to represent or narrativise. These difficulties encompass both the widespread fear that depictions of self-harm lead to imitative behaviour,
V Heney (19944432)
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Rural community-based participatory research with families of people who use drugs: key considerations from a multi-provincial research partnership

Harm Reduction Journal
Background North America continues to contend with an unregulated drug crisis that is impacting communities of all sizes. Community-based participatory research that meaningfully engages people who use drugs, families, and their wider communities is one ...
Holly Mathias, Elsie Duff, Petra Schulz, Sarah Auger, Antoinette Gravel-Ouellette, Teresa Lockhart, Willi McCorriston, Jenn McCrindle, Nyal Mirza, Em Pijl, Tyla Savard, Elaine Hyshka   +11 more
doaj   +1 more source

An audit of 12 cases of long COVID following the lightning process intervention examining benefits and harms

Journal of Family Medicine and Primary Care
To audit the outcomes of patients with long COVID after the lightning process intervention. Retrospective cross-sectional audit. Patients with long COVID were interviewed through telephone regarding their experience and response to the lightning process.
Bruce Arroll, Fiona Moir, Eloise Jenkins, David Benjamin Menkes   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Harmful Noise [PDF]

Occupational Medicine, 1956
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effects of green manuring on chemical characteristics and microecology of tobacco-growing soil in central henan

BMC Microbiology
Objective This study explored green manuring effects on microecology, carbon/nitrogen levels, and enzyme activity in tobacco-growing soils. Methods After 30,000 kg·hm⁻² overpressure and 28 days of natural decomposition, plants (Hordeum vulgare L.
Wei Liu, Xiaolong Chen, Yuanyuan Zhao, Hongzhi Shi   +3 more
doaj   +1 more source