Results 181 to 190 of about 518,464 (269)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Self-harm before and during imprisonment: cohort study of males in prison linking population-based routinely collected data in Wales. [PDF]

BJPsych Open
DelPozo-Banos M, Atkinson MD, Lee SC, John A.   +3 more
europepmc   +1 more source

Managerial approaches to mitigate police professionals’ online harms in the United Kingdom

Yen Nee Wong, Shane Horgan, Elizabeth Aston   +2 more
openalex   +1 more source

Harm Nijboer, De fatsoenering van het bestaan. Consumptie in Leeuwarden tijdens de Gouden Eeuw

, 2010
A.J. Schuurman
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perspectives from Young Australian Women with Lived Experience on Why Rates of Self-Harm Are Increasing: A Qualitative Study. [PDF]

Int J Environ Res Public Health
Hankin L, Hronis A, Whitton A, Tang S, Slade A, Christensen H, Calear AL, Boydell K, Rheinberger D.   +8 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Barriers and facilitators for self-harm prevention and surveillance: A cross-sectional study with primary health care nurses in Brazil. [PDF]

PLoS One
Vanzela AS, Silva Pedrollo LF, Silva AC, Martin IDS, da Silva BP, Dos Santos MADNB, Rodrigues J, Fernandes MA, Zanetti ACG, Giacon BCC, de Arruda GO, Vedana KGG.   +11 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Recurrent ICU admissions following deliberate self-poisoning: Clinical, ethical, and emotional pressures on critical care services. [PDF]

J Intensive Care Soc
Calder H, Sinha A.
europepmc   +1 more source