Results 191 to 200 of about 518,464 (269)

Keeping CRISPR under control: how bacteria fight viruses without harming themselves

, 2018
Addison V. Wright
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Solving the riddle by puzzling it out: overcoming the challenges of harm-benefit analysis by assembling a compound model and practice-oriented tool. [PDF]

Front Vet Sci
Hajosi D, Grimm H.
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Understanding healthcare utilisation for aboriginal people in New South Wales prisons with histories of self-harm and suicidal behaviour: a retrospective cohort study. [PDF]

BMC Public Health
Zeki R, Kaye S, Creighton G, Howard MVA, Shields R, Ellis A, Nicholls G, Hoey W, Nanayakkara V, Bowman J.   +9 more
europepmc   +1 more source

Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism [PDF]

Xiao‐Ming Xu, Ruhong Jiang, Yiming Han, Wo Wang, Ming Ai, Jianmei Chen, Jun Cao, Xiaorong Chen, Zhen Lv, Haoran Xu, Da-Qin Ding, Hong Su, Jing-Lan He, Qi Zhang, Lei Shi, Ning Du, Jinhui Hu, Li Kuang   +17 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Reducing self-harm in adolescents: the RISA-IPD comprehensive synopsis.

Health Technol Assess
Cottrell D, Walwyn R, Farrin A, Irving D, Fonagy P, Ougrin D, Stahl D, Wright J, Wright-Hughes A, RISA-IPD Collaborative Group.   +9 more
europepmc   +1 more source

A protocol for a rapid realist policy review (RRPR) of the impact of social determinants on self-harm and suicidal thoughts and behaviours in England. [PDF]

BMJ Open
Chen AHG, Michail M, Morales-Muñoz I, Wright N, Fenton SH.   +4 more
europepmc   +1 more source