Results 41 to 50 of about 824,404 (357)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

High-dose naloxone formulations are not as essential as we thought

Harm Reduction Journal
Naloxone is an effective FDA-approved opioid antagonist for reversing opioid overdoses. Naloxone is available to the public and can be administered through intramuscular (IM), intravenous (IV), and intranasal spray (IN) routes.
Paige M. Lemen, Daniel P. Garrett, Erin Thompson, Megan Aho, Christina Vasquez, Ju Nyeong Park   +5 more
doaj   +1 more source

Study of human rights violations faced by women who use drugs in Estonia

Harm Reduction Journal, 2018
Background Estonia continues to have the highest prevalence of HIV among people who inject drugs, and the highest overdose mortality, in the European Union.
Arune Kontautaite, Daria Matyushina-Ocheret, Maria Plotko, Mikhail Golichenko, Mart Kalvet, Lena Antonova   +5 more
doaj   +1 more source

Harm-reduction approaches for self-cutting in inpatient mental health settings:development and preliminary validation of the Attitudes to Self-cutting Management (ASc-Me) Scale [PDF]

, 2018
IntroductionHarm-reduction approaches for self-harm in mental health settings have been under-researched.AimTo develop a measure of the acceptability of management approaches for self-cutting in mental health inpatient settings.MethodsStage one: scale ...
Bowers, Bowers, Bowers, Briere, Cabrera-Nguyen, Cichetti, Dack, Duperouzel, Duxbury, Edwards, Field, Fontaine, George, Gutridge, Hair, Hallgren, Henson, Holley, Information Centre for Health and Social Care, James, James, Lindgren, McAllister, Meltzer, Mokkink, Muir-Cochrane, National Institute for Clinical Excellence, National Institute of Health and Clinical Evidence (NICE), NHS Information Centre for Health and Social Care, O'Donovan, O'Donovan, Patterson, Pembroke, Pengelly, Sansone, Shannon, Sinclair, Sullivan, Swannell, Tsiachristas, Urbina, Whittington, Wilstrand, Worthington, Zhang   +44 more
core   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Sustainability of opioid agonist therapy programmes in Belarus, the Republic of Moldova, Tajikistan and Ukraine in the context of transition from Global Fund support during 2020–2023

Harm Reduction Journal
Background Most national programmes of opioid agonist therapy (OAT) in Eastern Europe and Central Asia are at a critical juncture for building their sustainability due to decreasing support from the Global Fund and other international HIV funders ...
Raminta Stuikyte, Ivan Varentsov, Naimdzhon Malikov, Sergii Dvoriak, Myroslava Filippovych, Alisher Latypov, Aleksei Kralko, Ala Iatco, Catherine Cook   +8 more
doaj   +1 more source

Reducing the nicotine content of tobacco by grafting with eggplant

BMC Plant Biology, 2020
Background Nicotine is a stimulant and potent parasympathomimetic alkaloid that accounts for 96–98% of alkaloid content. A reduction in the amount of nicotine in cigarettes to achieve a non-addictive level is necessary.
Mengjuan Ren, Mengyue Zhang, Huijuan Yang, Hongzhi Shi   +3 more
doaj   +1 more source

The Bronze Age of drug checking: barriers and facilitators to implementing advanced drug checking amidst police violence and COVID-19

Harm Reduction Journal, 2022
Objectives Unpredictable fluctuations in the illicit drug market increase overdose risk. Drug checking, or the use of technology to provide insight into the contents of illicit drug products, is an overdose prevention strategy with an emerging evidence ...
Jennifer J. Carroll, Sarah Mackin, Clare Schmidt, Michelle McKenzie, Traci C. Green   +4 more
doaj   +1 more source

Use of harm reduction strategies in an occupational therapy life skills intervention [PDF]

, 2013
Thesis (M.S.)--Boston UniversityObjectives of Study: Harm reduction intervention strategies have the potential to support positive health outcomes. However, no studies have explored how these strategies can be implemented in an occupational therapy ...
Hellman, Miranda Renee
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source