Results 51 to 60 of about 15,469,363 (346)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Changes in gene expression, cell physiology and toxicity of the harmful cyanobacterium Microcystis aeruginosa at elevated CO2

Frontiers in Microbiology, 2015
Rising CO2 concentrations may have large effects on aquatic microorganisms. In this study, we investigated how elevated pCO2 affects the harmful freshwater cyanobacterium Microcystis aeruginosa.
Giovanni eSandrini, Serena eCunsolo, Merijn eSchuurmans, Merijn eSchuurmans, Hans eMatthijs, Jef eHuisman   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Palestinian Comparative Jurisprudence and violation of the Lease Contract – A comparative study in light of the landlords and tenants’ law and Majalla

International Review of Law, 2021
The research analyzed the role of Palestinian and comparative jurisprudence in achieving a balance between interests in the lease contract in the violation of contract terms as a reason for eviction by adoption of reasonable standards.
إبراهيم خالد يحيى
doaj   +2 more sources

Harmful Microalgae Exhibit Broad Environmental Adaptability in High‐Salinity Area Across the Dafengjiang River Estuary

Ecology and Evolution
Harmful algal blooms (HABs) often occur in estuaries due to their unique environmental heterogeneity, posing significant environmental and human health risks. However, there is limited understanding of the community composition and community‐level change
Jiongqing Huang, Huaxian Zhao, WeiJun Wang, Xinyi Qin, Pengbin Wang, Qinghua Hou, Qingxiang Chen, Gonglingxia Jiang, Ke Dong, Tao Jiang, Yang Pu, Nan Li   +11 more
doaj   +1 more source

Diel variation in gene expression of the CO2-concentrating mechanism during a harmful cyanobacterial bloom

Frontiers in Microbiology, 2016
Dense phytoplankton blooms in eutrophic waters often experience large daily fluctuations in environmental conditions. We investigated how this diel variation affects in situ gene expression of the CO2-concentrating mechanism (CCM) and other selected ...
Giovanni eSandrini, Robert eTann, Jasper Merijn Schuurmans, Jasper Merijn Schuurmans, Sebastiaan evan Beusekom, Hans C.P. Matthijs, Jef eHuisman   +6 more
doaj   +1 more source

Climate Changes, Natural Resources Depletion, COVID-19 Pandemic, and Russian-Ukrainian War: What Is the Impact on Habits Change and Mental Health?

International Journal of Environmental Research and Public Health, 2022
Climate Change, Natural Resources Depletion, COVID-19, and Wars are some of the great challenges of our time. The consequences will affect psychological well-being and could have a harmful impact on mental health.
B. Barchielli, C. Cricenti, F. Gallé, Elita Anna Sabella, F. Liguori, G. Da Molin, G. Liguori, G. B. Orsi, A. Giannini, S. Ferracuti, C. Napoli   +10 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Mitigating Harmful Cyanobacterial Blooms in a Human- and Climatically-Impacted World

Life, 2014
Bloom-forming harmful cyanobacteria (CyanoHABs) are harmful from environmental, ecological and human health perspectives by outcompeting beneficial phytoplankton, creating low oxygen conditions (hypoxia, anoxia), and by producing cyanotoxins ...
Hans W. Paerl
doaj   +1 more source