Results 51 to 60 of about 692,979 (283)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A gap theorem for $\alpha$-harmonic maps between two-spheres [PDF]

, 1914
In this paper we consider approximations introduced by Sacks-Uhlenbeck of the harmonic energy for maps from $S^2$ into $S^2$. We continue the analysis in [6] about limits of $\alpha$-harmonic maps with uniformly bounded energy.
Lamm, Tobias, Malchiodi, Andrea, Micallef, Mario   +2 more
core   +5 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of the Supply Voltage Variation on the Conducted Emission in the Frequency Range up to 150 kHz Injected into the Power Grid by CFL and LED Lamps—Case Study

Applied Sciences
In normal operating conditions, the mains voltage level provided by low-voltage distribution networks follows time-varying patterns within permissible limits.
Wojciech Frydlewicz, Łukasz Michalec, Paweł Kostyła, Dominika Kaczorowska, Tomasz Sikorski   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Harmonic analysis and the Riemann-Roch theorem

, 2011
This paper is a continuation of papers: arXiv:0707.1766 [math.AG] and arXiv:0912.1577 [math.AG]. Using the two-dimensional Poisson formulas from these papers and two-dimensional adelic theory we obtain the Riemann-Roch formula on a projective smooth ...
A. N. Parshin, A. N. Parshin, D. Osipov, D. V. Osipov, D. V. Osipov, D. V. Osipov, D. V. Osipov, J.-P. Serre   +7 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On X ̃-frames and conjugate systems in Banach spaces

Sahand Communications in Mathematical Analysis, 2014
The generalization of p-frame in Banach spaces is considered in this paper. The concepts of an X~-frame and a system conjugate to X~-frame were introduced. Analogues of the results on the existence of conjugate system were obtained.
Migdad Ismailov, Afet Jabrailova
doaj  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Discrete harmonic analysis on a Weyl alcove

, 2013
We introduce a representation of the double affine Hecke algebra at the critical level q=1 in terms of difference-reflection operators and use it to construct an explicit integrable discrete Laplacian on the Weyl alcove corresponding to an element in the
Emsiz, E., van Diejen, J. F.
core   +1 more source