Results 41 to 50 of about 24,852 (245)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mathematics, 2022 This article is the further work of previous papers and also the first study to adopt the elliptic integral approach to solve the forced nonlinear structural acoustic problem.
Yiu-Yin Lee
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Goals and Strategies for Open Fan Design
International Journal of Turbomachinery, Propulsion and PowerThis paper highlights recent activities associated with the design of an uninstalled open fan propulsor for next-generation civil aircraft in the high-subsonic flight regime.
Carola Rovira Sala +4 more
doaj +1 more source
HARMONIC BALANCE ANALYSIS OF THE GENERALIZED CHUA'S CIRCUIT [PDF]
International Journal of Bifurcation and Chaos, 2006 In this paper, the harmonic balance analysis of Generalized Chua's circuit exhibiting n-scroll attractors has been accomplished. The dual-input describing functions of the piecewise-linear characteristics of Chua's diode have been obtained and based on the harmonic balance principle, the existence and the locations of the n-scrolls have been verified.
Savacı, Ferit Acar, Günel, Serkan
openaire +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Harmonic balance method for MEMS oscillators
Frontiers in PhysicsIntroductionMicro-Electro-Mechanical System (MEMS) oscillators play a pivotal role in diverse applications such as biosensors and wearable sensors. To optimize their performance and ensure reliability, exploring their periodic properties and pull-in ...
Xian-He Lei, Yutong Cui
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source