Results 61 to 70 of about 178,536 (300)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
International Journal of Turbomachinery, Propulsion and Power, 2021 Unsteady pressure fluctuations measured by fast-response pressure transducers mounted in a low-pressure turbine cascade are compared to unsteady simulation results. Three differing simulation approaches are considered, one time-integration method and two
Jan Philipp Heners +5 more
doaj +1 more source
Frequency-Domain Analysis of Linear Time-Periodic Systems [PDF]
, 2004 In this paper, we study convergence of truncated representations of the frequency-response operator of a linear time-periodic system. The frequency-response operator is frequently called the harmonic transfer function. We introduce the concepts of input,
Bernhardsson, Bo +2 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
, 2007 A general numerical technique is proposed for the assessment of the stability of periodic solutions and the determination of bifurcations for limit cycles in autonomous nonlinear systems represented by ordinary differential equations in the differential ...
Bai +16 more
core +1 more source
Refined Analytical Approximations to Limit Cycles for Non-Linear Multi-Degree-of-Freedom Systems [PDF]
, 2019 This paper presents analytical higher order approximations to limit cycles of an autonomous multi-degree-of-freedom system based on an integro-differential equation method for obtaining periodic solutions to nonlinear differential equations.
Lewis, Andrew
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Shock and Vibration, 2021 This study develops a modified elliptic harmonic balance method (EHBM) and uses it to solve the force and displacement transmissibility of a two-stage geometrically nonlinear vibration isolation system.
Weilei Wu, Bin Tang
doaj +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Идентификация параметров нелинейностей электромеханических систем энергетическим методом [PDF]
, 2013 This paper presents a mathematical apparatus for determining the parameters of nonlinear electromechanical system, represented by piecewise linear functions on the basis of the harmonic approximation in conjunction with the energy method.
Мосюндз, Дарья Андреевна
core