Results 41 to 50 of about 52,366 (261)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Harmonic m-Preinvex Functions and Inequalities

International Journal of Analysis and Applications, 2018
In this paper, we introduce a new class of harmonic functions, which is called harmonic mpreinvex functions for a fixed m. Some Hermite-Hadamard inequality for harmonic m-preinvex functions are derived. Several special cases are discussed as applications
Muhammad Aslam Noor, Khalida Inayat Noor, Sabah Iftikhar, Awais Gul Khan   +3 more
doaj   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

HARMONIC FUNCTION

مجلة جامعة الزيتونة, 2022
 In this paper, we present an innovative idea of the harmonic functions. In order to do this, we first present the most important theories related to harmonic functions and put forward the idea of harmonic conjugate.
Abdulbasit Abdulrahman, Zaynab Khalleefah, Omar Elhasadi   +2 more
doaj  

BASIC DONKIN'S DIFFERENTIAL OPERATORS FOR HOMOGENEOUS HARMONIC FUNCTIONS

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2019
It is shown that there are the differential operators that transform three-dimensional homogeneous harmonic functions into new three-dimensional homogeneous harmonic functions.
Berdnikov Alexander, Gall Lidia, Gall Nikolaj, Solovyev Konstantin   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weighted lipschitz continuity, Schwarz–Pick's lemma and Landau–Bloch's theorem for hyperbolic-harmonic mappings in ℂn

Mathematical Modelling and Analysis, 2013
In this paper, we discuss some properties on hyperbolic-harmonic functions in the unit ball of ℂ n . First, we investigate the relationship between the weighted Lipschitz functions and the hyperbolic-harmonic Bloch spaces.
Shaolin Chen, Saminathan Ponnusamy, Xiantao Wang   +2 more
doaj   +1 more source

A Path Planning Algorithm for a Dynamic Environment Based on Proper Generalized Decomposition

Mathematics, 2020
A necessity in the design of a path planning algorithm is to account for the environment. If the movement of the mobile robot is through a dynamic environment, the algorithm needs to include the main constraint: real-time collision avoidance.
Antonio Falcó, Lucía Hilario, Nicolás Montés, Marta C. Mora, Enrique Nadal   +4 more
doaj   +1 more source

A Study on Harmonic Functions

Proceedings of the Bulgarian Academy of Sciences
The class of functions that have bounded boundary rotation and bounded radius rotation are the generalization of the convex and the starlike functions, respectively. The concept of such functions was introduced by Löwner [1]. But he did not use the present terminology.
Uçar, Mehmet Fatih, Özkan Uçar, Hatice Esra   +1 more
openaire   +2 more sources