Results 161 to 170 of about 140,378 (296)

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Research on finite element helical line direction modification of flexspline profile in harmonic reducer

Jixie qiangdu
To solve the stress concentration problem caused by tooth interference and insufficient tooth surface contact during the operation of harmonic reducers, an axial modification method based on the finite element method (FEM) was proposed.
ZHOU Weihong, WANG Zhonghou, CHEN Mingzhi, WANG Fa, MA Jingkai   +4 more
doaj  

Nonlinear Ultrasonic Time-Domain Identification Based on Chaos Sensitivity and Its Application to Fatigue Detection of U71Mn Rail Steels. [PDF]

Sensors (Basel)
Li H, Cheng M, Luo C, Zhang W, Wu J, Ma H.   +5 more
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Phase-multiplied interferometry via cavity dynamics for resolution-enhanced coherent ranging. [PDF]

Light Sci Appl
Wang Y, Liu J, Lin C, Xu X, Wang Y, Yang X, Xie B, Han J, Wu T, Lin X, Cao L, Sun H, Tan Y.   +12 more
europepmc   +1 more source

Interference analysis, spectrum harmonization and scheduling

Interference analysis spectrum harmonization and ...
openaire   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

Quantum interference and occupation control in high harmonic generation from monolayer WS₂. [PDF]

Nat Commun
Kim M, Kim T, Galler A, Kim D, Chacon A, Gong X, Yang Y, Fang R, Watanabe K, Taniguchi T, Kim BJ, Chae SH, Jo MH, Rubio A, Neufeld O, Kim J.   +15 more
europepmc   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Shaping Ultrafast Pulses for Enhanced Resonant Nonlinear Interactions. [PDF]

Nano Lett
Meron O, Nehemia S, Arieli U, Suchowski H.   +3 more
europepmc   +1 more source