Results 31 to 40 of about 86,238 (261)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
An optimal double inequality among the one-parameter, arithmetic and harmonic means
Journal of Numerical Analysis and Approximation Theory, 2010 For \(p\in\mathbb{R}\), the one-parameter mean \(J_{p}(a,b)\), arithmetic mean \(A(a,b)\), and harmonic mean \(H(a,b)\) of two positive real numbers \(a\) and \(b\) are defined by\begin{equation*}J_{p}(a,b)=\begin{cases}\tfrac{p(a^{p+1}-b^{p+1})}{(p+1)(a^
Wang Miao-Kun, Qiu Ye-Fang, Chu Yu-Ming
doaj +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Introducing the Harmonic Mean Solving a Tourist’s Problem
Epidemiology, Biostatistics and Public Health, 2015 This exercise can be given to a group of students with basic knowledge of mathematics and physics at the beginning of a lesson. We can imagine that there will be some students that will solve the exercise using the “common sense” solution recalling basic
Anna Bossi, Anna Zolin
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
New heuristic for harmonic means clustering [PDF]
Journal of Global Optimization, 2014 It is well known that some local search heuristics for K-clustering problems, such as k-means heuristic for minimum sum-of-squares clustering occasionally stop at a solution with a smaller number of clusters than the desired number K. Such solutions are called degenerate. In this paper, we reveal that the degeneracy also exists in K-harmonic means (KHM)
Emilio Carrizosa +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Vector Decimation Harmonic Mean-Based Algorithm for Online Acoustic Feedback Active Noise Control
IEEE AccessThis research addresses the acoustic feedback and stability performance of Active Noise Control (ANC) systems. The Filtered Cross Least Mean Square (FxLMS) algorithm is one of ANC’s most successful adaptive algorithms for reducing undesired noise.
Suman Turpati +6 more
doaj +1 more source
On the Mean-Value Property of Harmonic Functions [PDF]
Proceedings of the American Mathematical Society, 1971 In this note we show that if the areal mean-value theorem holds for a plane domain (subject to a mild regularity condition) for all integrable harmonic functions, then the domain must be a disk. It is also shown that if a plane domain with finite area has at least two boundary components which are continua then the mean-value property cannot hold for ...
Goldstein, Myron, Ow, Wellington H.
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