Results 31 to 40 of about 2,051 (212)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An optimal double inequality among the one-parameter, arithmetic and harmonic means

Journal of Numerical Analysis and Approximation Theory, 2010
For \(p\in\mathbb{R}\), the one-parameter mean \(J_{p}(a,b)\), arithmetic mean \(A(a,b)\), and harmonic mean \(H(a,b)\) of two positive real numbers \(a\) and \(b\) are defined by\begin{equation*}J_{p}(a,b)=\begin{cases}\tfrac{p(a^{p+1}-b^{p+1})}{(p+1)(a^
Wang Miao-Kun, Qiu Ye-Fang, Chu Yu-Ming
doaj   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Introducing the Harmonic Mean Solving a Tourist’s Problem

Epidemiology, Biostatistics and Public Health, 2015
This exercise can be given to a group of students with basic knowledge of mathematics and physics at the beginning of a lesson. We can imagine that there will be some students that will solve the exercise using the “common sense” solution recalling basic
Anna Bossi, Anna Zolin
doaj   +1 more source

Bounds for the Convex Combination of Contra-harmonic and Harmonic Means by the Generalized Logarithmic Mean

European Journal of Pure and Applied Mathematics, 2022
We verify the optimal inequalities between generalized logarithmic mean and the weighted arithmetic mean of contra-harmonic and harmonic means.
Annop Sonubon, Somsak Orankitjaroen, Kamsing Nonlaopon   +2 more
openaire   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Vector Decimation Harmonic Mean-Based Algorithm for Online Acoustic Feedback Active Noise Control

IEEE Access
This research addresses the acoustic feedback and stability performance of Active Noise Control (ANC) systems. The Filtered Cross Least Mean Square (FxLMS) algorithm is one of ANC’s most successful adaptive algorithms for reducing undesired noise.
Suman Turpati, Ajay Roy, Tathababu Addepalli, Mohammed Alkahtani, Abdullatif Hakami, Ahmad Faiz Minai, Abdallah Hammad   +6 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Asymptotically Mean Value Harmonic Functions in Doubling Metric Measure Spaces

Analysis and Geometry in Metric Spaces, 2022
We consider functions with an asymptotic mean value property, known to characterize harmonicity in Riemannian manifolds and in doubling metric measure spaces.
Adamowicz Tomasz, Kijowski Antoni, Soultanis Elefterios   +2 more
doaj   +1 more source