Results 31 to 40 of about 81,520 (260)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The F-measure for Research Priority

Journal of Data and Information Science, 2018
In this contribution we continue our investigations related to the activity index (AI) and its formal analogs. We try to replace the AI by an indicator which is better suited for policy applications.
Rousseau Ronald
doaj   +1 more source

Harmonic Mean Operator Based MADM-Strategy under SVPN-Set Environment [PDF]

Neutrosophic Sets and Systems
By using single-valued pentapartitioned neutrosophic set (briefly SVPN-set), one can express uncertainty events having incomplete, indeterminate, and erroneous information in practical applications.
Bimal Shil, Suman Das, Rakhal Das, Binod Chandra Tripathy   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An optimal double inequality among the one-parameter, arithmetic and harmonic means

Journal of Numerical Analysis and Approximation Theory, 2010
For \(p\in\mathbb{R}\), the one-parameter mean \(J_{p}(a,b)\), arithmetic mean \(A(a,b)\), and harmonic mean \(H(a,b)\) of two positive real numbers \(a\) and \(b\) are defined by\begin{equation*}J_{p}(a,b)=\begin{cases}\tfrac{p(a^{p+1}-b^{p+1})}{(p+1)(a^
Wang Miao-Kun, Qiu Ye-Fang, Chu Yu-Ming
doaj   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Introducing the Harmonic Mean Solving a Tourist’s Problem

Epidemiology, Biostatistics and Public Health, 2015
This exercise can be given to a group of students with basic knowledge of mathematics and physics at the beginning of a lesson. We can imagine that there will be some students that will solve the exercise using the “common sense” solution recalling basic
Anna Bossi, Anna Zolin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Vector Decimation Harmonic Mean-Based Algorithm for Online Acoustic Feedback Active Noise Control

IEEE Access
This research addresses the acoustic feedback and stability performance of Active Noise Control (ANC) systems. The Filtered Cross Least Mean Square (FxLMS) algorithm is one of ANC’s most successful adaptive algorithms for reducing undesired noise.
Suman Turpati, Ajay Roy, Tathababu Addepalli, Mohammed Alkahtani, Abdullatif Hakami, Ahmad Faiz Minai, Abdallah Hammad   +6 more
doaj   +1 more source