Results 71 to 80 of about 493,296 (323)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Bounds for the Neuman–Sándor Mean in Terms of the Arithmetic and Contra-Harmonic Means [PDF]
, 2022 Wen Hui Li, Peng Miao, Bai‐Ni Guo
openalex +1 more source
Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel +5 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
, 2016 We briefly describe some well-known means and their properties, focusing on the relationship with integer sequences. In particular, the harmonic numbers, deriving from the harmonic mean, motivate the definition of a new kind of mean that we call the ...
Abrate, Marco +3 more
core +1 more source
Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
wiley +1 more source
A mixed arithmetic-mean-harmonic-mean matrix inequality
Linear algebra and its applications, 1996 A conjecture involving a mixed arithmetic-mean-geometric-mean inequality was recently proved. We give an analogous mixed arithmetic-mean-harmonic-mean inequality for Hermitian matrices. Mixed arithmetic-geometric and harmonic-geometric-mean inequalities for two matrices are also given.
Mond, B., Pečarić, J. E.
openaire +4 more sources
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Efficient harmonic oscillator chain energy harvester driven by colored noise
Scientific Reports, 2020 We study the performance of an electromechanical harmonic oscillator chain as an energy harvester to extract power from finite-bandwidth ambient random vibrations, which are modelled by colored noise.
M. Romero-Bastida, Juan M. López
doaj +1 more source