Results 51 to 60 of about 10,789 (253)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Phase-Locked Feed-Forward Stabilization for Dual-Comb Spectroscopy

Ultrafast Science
Sustained mutual coherence between 2 combs over extended periods is a prerequisite for dual-comb spectroscopy (DCS), particularly in achieving high-resolution molecular spectroscopy and precise spectral measurements.
Mithun Pal, Alexander Eber, Lukas Fürst, Emily Hruska, Marcus Ossiander, Birgitta Bernhardt   +5 more
doaj   +1 more source

Peculiar double-periodic pulsation in RR Lyrae stars of the OGLE collection. I. Long-period stars with dominant radial fundamental mode

, 2016
We present the discovery of a new, peculiar form of double-periodic pulsation in RR Lyrae stars. In four, long-period ($P>0.6$ d) stars observed by the Optical Gravitational Lensing Experiment, and classified as fundamental mode pulsators (RRab), we ...
Bakowska, K., Prudil, Z., Skarka, M., Smolec, R.   +3 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A FEM-based method using harmonic overtones to determine the effective elastic, dielectric, and piezoelectric parameters of freely vibrating thick piezoelectric disks

IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2013
To gain an understanding of the electroelastic properties of tactile piezoelectric sensors used in the characterization of soft tissue, the frequency-dependent electric impedance response of thick piezoelectric disks has been calculated using finite element modeling.
Jonsson, Ulf G., Andersson, Britt M., Lindahl, Olof A.   +2 more
openaire   +4 more sources

Oscillations of vertically integrated relativistic tori -II. Axisymmetric modes in a Kerr spacetime

, 2004
This is the second of a series of papers investigating the oscillation properties of relativistic, non-selfgravitating tori orbiting around black holes. Extending the work done in a Schwarzschild background, we here consider the axisymmetric oscillations
Montero, Pedro J., Rezzolla, Luciano, Yoshida, Shin'ichirou   +2 more
core   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

The Core-Cusp Problem in Cold Dark Matter Halos and Supernova Feedback: Effects of Oscillation

, 2014
This study investigates the dynamical response of dark matter (DM) halos to recurrent starbursts in forming less-massive galaxies to solve the core-cusp problem.
Burkert, de Blok, Del Popolo, Fukushige, Fukushige, Go Ogiya, Ishiyama, Jing, Klypin, Komatsu, Komatsu, Kuzio de Naray, Kuzio de Naray, Mac Low, Macciò, Masao Mori, McQuinn, McQuinn, Moore, Mori, Mori, Mori, Navarro, Ogiya, Ogiya, Oh, Oh, Silich, Spekkens, Spergel, Stinson, Swaters, Weinberg, Weisz, Widrow, Yoshii, Yoshii   +36 more
core   +1 more source