Results 211 to 220 of about 873,634 (289)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

The private solution trap in collective action problems across 34 nations. [PDF]

Proc Natl Acad Sci U S A
Malthouse E, Pilgrim C, Sgroi D, Accerenzi M, Alfonso A, Ashraf RU, Baard M, Banerjee S, Belianin A, Bhattacharjee S, Bhattacharya M, Brañas-Garza P, Cárdenas JC, Carriquiry M, Choi S, Clochard GJ, Denzon EE, Dessoulavy-Sliwinski B, Dini G, Dong L, Ertl A, Exadaktylos F, Filiz-Ozbay E, Flecke SL, Galeotti F, Garcia-Muñoz T, Hanaki N, Hollard G, Horn D, Huang L, İriş D, Kiss HJ, Koch J, Kovářík J, Kwarteng OKB, Lange A, Leites M, Leung TH, Lim W, Morren M, Nockur L, Okyere CY, Oudah M, Ozkes AI, Page L, Park J, Pfattheicher S, Proestakis A, Ramos C, Ramos-Sosa M, Ashraf MS, Sanjaya MR, Schwaiger R, Sene O, Song F, Spycher S, Staněk R, Tanchingco N, Tavoni A, Te Velde V, Vázquez-De Francisco MJ, Visser M, Wang JT, Wang W, Weng WC, Werner K, Wijayanti A, Winkler R, Wooders J, Ying L, Zhen W, Hills T.   +71 more
europepmc   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Utility of live aided Cortical Evoked Potential (CAEP) for optimizing programming of cochlear implants. [PDF]

Codas
Thangaraj MS, Priscilla V, Johnson J.
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Successful Transcatheter Pulmonary Valve Replacement Via the Azygous Vein in a Patient With Interrupted Inferior Vena Cava. [PDF]

JACC Case Rep
Forbes KL, Prieto L, Duarte-Caceres D.
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Reassessing Baumrind's framework: a systematic review of cultural adaptations and emerging parenting patterns in diverse societies. [PDF]

Psicol Reflex Crit
Widiastuti AA, Atmoko A, Eva N, Soares D.   +3 more
europepmc   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Biotuner: A python toolbox integrating music theory and signal processing for harmonic analysis of physiological and natural time series. [PDF]

Brain Inform
Bellemare-Pepin A, Jerbi K.
europepmc   +1 more source