Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv +29 more
wiley +1 more source
Eco-Friendly Approaches to Enhance Dental Aesthetics and Patient Satisfactions Using Digital Smile Design: A Systematic Review. [PDF]
Reviansyah FH +6 more
europepmc +1 more source
EMOTION-AWARE COLOR THEORY: COMPUTATIONAL MODELING OF ARTISTIC COLOR HARMONIES IN DESIGN
Suman Pandey +5 more
openalex +2 more sources
Solid Harmonic Wavelet Bispectrum for Image Analysis
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown +3 more
wiley +1 more source
Splicing-aware scRNA-Seq resolution reveals execution-ready programs in effector Tregs. [PDF]
Lukyanov DK +8 more
europepmc +1 more source
Perspective: Hollow Core Optical Fibres for Ultraviolet and Visible Wavelengths
Hollow core optical fibres bypass material constraints that limit optical fibres at ultraviolet and visible wavelengths. However, their challenging fabrication has limited their development, and significant gains in performance remain possible. In this perspective we outline approaches to enable the next generation of fibres for shorter wavelengths ...
Robbie Mears +5 more
wiley +1 more source
A systematic characterization of fibroblast subtypes and heterogeneity. [PDF]
Zhu X, Kang H, Zhao Z, Jia P.
europepmc +1 more source
Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
wiley +1 more source
Drawing therapy based on embodied cognition theory on emotional expression and social behavior in students with autism: a mixed-methods study. [PDF]
Li G, Wei D, Xing Y, Li Y, Song W.
europepmc +1 more source
Integrative analysis of molecular mechanisms in prostate cancer via single-cell RNA sequencing and weighted gene co-expression network analysis. [PDF]
Zhai J +6 more
europepmc +1 more source

