Results 161 to 170 of about 139,092 (290)

New biosensors and transgenic mice for multiplex cGMP imaging

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters   +6 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Advancing Mobile Neuroscience: A Novel Wearable Backpack for Multi-Sensor Research in Urban Environments. [PDF]

open access: yesSensors (Basel)
Amaro J   +12 more
europepmc   +1 more source

Physical attractiveness, drug taking and gender differences

open access: yesCanadian Journal of Economics/Revue canadienne d'économique, EarlyView.
Abstract This study investigates the relationship between adolescent physical attractiveness and drug‐taking behaviour, emphasizing the human capital and “pretty girl” effects on the decision to use drugs. Through the human capital effect, physically attractive adolescents are better positioned to accumulate human capital at a young age compared to ...
Andy Chung, Junsen Zhang
wiley   +1 more source

Expression of dementia biomarkers in Appalachian and non-Appalachian ELVO patients during thrombectomy. [PDF]

open access: yesFront Neurosci
Anil N   +12 more
europepmc   +1 more source

A Right‐Wing Populist Turn in the Conservative Party of Canada? Continuities and Ruptures Under the Leadership of Pierre Poilievre (2022–2025)

open access: yesCanadian Review of Sociology/Revue canadienne de sociologie, EarlyView.
ABSTRACT Since his election as leader of the Conservative Party of Canada (CPC) in 2022, Pierre Poilievre has been associated with populism in media and political discourse, with implicit and explicit comparisons to Donald Trump. This article investigates the validity of such assessments by applying “complex” theories of populism, which conceptualize ...
Efe Peker, Emily Laxer, Rémi Vivès
wiley   +1 more source

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