Results 91 to 100 of about 4,205 (287)
Advanced Science, EarlyView.Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee +9 more
wiley +1 more source
DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut
Advanced Science, EarlyView.Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su +16 more
wiley +1 more source
International Journal of Agricultural Research, Innovation and TechnologyTillage practices constitute the major initial applications of farm power and machinery during crop cultivation. They comprise all soil-related manipulations aimed at preparing a good seedbed for appropriate crop growth.
Engonwie Sharon Mbachan +1 more
doaj +1 more source
Automatic adjustment of harrowing intensity in cereals using digital image analysis [PDF]
, 2020 Roland Gerhards +5 more
openalex +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
JTSL (Jurnal Tanah dan Sumberdaya Lahan), 2017 The use of agricultural mechanization in the form of tractors and earth moving will have an impact on soil porosity, soil bulk density and soil's ability to store water.
Carolina Eva Nita +2 more
doaj
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
Zasobność glebowego banku nasion chwastów w zależności od sposobu regulacji zachwaszczenia
Agronomy Science, 2007 A weed seed bank store of 0–1 and 1–10 soil layers, in dependence on different weed control measures used for winter wheat, was investigated. The treatments were: A – without any measure, B – harrowing in Autumn, GS 09–10, C – harrowing in Spring, GS 24 ...
MARIA JĘDRUSZCZAK +2 more
doaj
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source