Results 61 to 70 of about 21,886 (243)
Development of Piezoelectric Harvesters with Integrated Trimming Devices
Applied Sciences, 2018 Piezoelectric cantilever harvesters have a large power output at their natural frequency, but in some applications the frequency of ambient vibrations is different from the harvester’s frequency and/or ambient vibrations are periodic with some ...
Alberto Doria +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
AgricultureTo address longstanding challenges in sea buckthorn harvesting—such as the absence of effective harvesting principles, inefficient traditional manual and semi-mechanised methods, and rising labour costs—this study developed a self-propelled harvester ...
Jian Song +7 more
doaj +1 more source
Ciência e Agrotecnologia, 2011 Objetivou-se, no presente trabalho, realizar uma avaliação ergonômica de uma colhedora de cana-de-açúcar, localizada no município de Barra Bonita, estado de São Paulo, em janeiro de 2007.
Carla Bento da Silva +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Autonomous Offroad Vehicle Real-Time Multi-Physics Digital Twin: Modeling and Validation
MachinesThe use of physical vehicles and environments during vehicle research and development is highly resource-intensive, particularly for autonomous vehicles.
Mattias Lehto +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Design and Test of a Grain Cleaning Loss Monitoring Device for Wheat Combine Harvester
AgricultureAs the world’s first large grain crop, wheat in its mechanized harvesting process faces a serious problem, namely, when the combine harvester operating parameters are not set reasonably, it leads to increased losses of wheat kernels to an extent ...
Zhe Qu +6 more
doaj +1 more source